Biostatistics, Modeling, and Data Management

生物统计、建模和数据管理核心(核心C)的目的是提供 为所有实验的设计、开发提供全面、多学科的资源 适当和创新的统计方法，制定和应用适当的动力学 用于解释数据、统计分析和结果汇总的模型。核心拥有 以下是总体目标：提供设计方面的统计和建模咨询与协作， 进行、分析和解释所有项目研究报告和核心内容，并提供、管理 并维护一个支持研究项目和核心的高质量研究数据库，同时 保护所有主题数据的机密性。具体目标是：(1)协调管理 开展统计活动，以确保调查人员随时获得统计咨询和支助。 (2)在实验和研究的设计方面提供统计专业知识，包括研究建议 开发、分析方法、样本量确定、随机化程序和计划 中期审查和最终分析。(3)为所有使用成像的项目提供动力学建模专家 以测量生理参数。(4)提供数据分析和提取，以获得必要的 来自项目数据的信息。(5)协助编写统计和建模组件 手稿。(6)审查所有研究的完整性和统计合理性。(七)保持 配备最新统计分析软件的计算设施，以支持所有项目调查人员。 (八)开展生物统计学方法论研究，研究项目实施中出现的实际问题 项目。(9)根据需要开发新的建模方法，以最大限度地利用每种方法 调查员的数据。(10)提供以计算机为基础的工具，方便储存和检索 在拟议研究中产生的数据，从而创建和维护一个集中的关系 提供对公共资源和信息的访问的数据库。(十一)确保数据的准确性 通过基于软件的数据一致性和质量控制系统在数据库中维护数据。(12) 组织和维护数据库，以最大限度地提高准确性和可访问性，同时保持严格的 保密协议。(13)提供现有人口和资源的详细说明 以及未来的调查人员。(十四)提供高质量的数据录入服务。

The purpose of the Biostatistics, Modeling, and Data Management Core (Core C) is to provide a comprehensive, multi-disciplinary resource for the design of all experiments, development of appropriate and innovative statistical methodology, development and application of appropriate kinetic models to intrepret the data, statistical analysis, and summarization of results. The Core has the following overall goals: to provide statistical and modeling consulting and collaboration on the design, conduct, analysis and interpretation of all project research studies and cores, and to provide, manage and maintain a high-quality research database that supports the research projects and cores while preserving the confidentiality of all subject data. The specific aims are to: (1) Coordinate and manage statistical activities to ensure investigators have ready access to statistical consultation and support. (2) Provide statistical expertise in the design of experiments and studies, including research proposal development, analysis methods, sample size determination, randomization procedures, and plans for interim reviews and final analysis. (3) Provide kinetic modeling expertice for all projects using imaging to measure physiologic parameters. (4) Provide data analysis and extraction to obtain the necessary information from project data. (5) Assist with the writing of statistical and modeling components of manuscripts. (6) Review the integrity and statistical soundness of all studies. (7) Maintain a computing facility with up-to-date software for statistical analysis to support all project investigators. (8) Conduct biostatistical methodology research on practical problems arising from performance of the projects. (9) Develop new modeling approaches as necessary to maximize the utility of each investigator's data. (10) Provide computer-based tools that facilitate the storage and retrieval of the data generated in the proposed research, thereby creating and maintaining a centralized relational database that provides access to common resources and information. (11) Ensure the accuracy of the data maintained in the database by software based data consistency and quality control systems. (12) Organize and maintain the database to maximize accuracy and accessibility while maintaining strict confidentiality. (13) Provide detailed descriptions of the available populations and resources for current and future investigators. (14) Provide high-quality data entry services.