MONKEY ALCOHOL TISSUE RESEARCH RESOURCE (MATRR)

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 偶尔或长期摄入过量的酒精，与影响大脑和行为以及其他器官损伤的医学疾病并存。关于大量饮酒的风险和后果（包括器官损伤的机制）的大部分已知信息都来自啮齿动物研究或回顾性人类记录。猴子酒精组织研究资源（MATRR）是一个独特的死后组织库，以确保长期饮酒动物的组织，以及其相关的饮酒和遗传信息，可用于更广泛的酒精研究社区，确保减少用于研究的动物数量。 该组织来源于在ONPRC（恒河猴和食蟹猴）和维克森林（vervet）饲养的三种猴中乙醇自我给药的标准方案。该资源将为与饮酒风险和后果相关的假设检验提供新数据，并有助于双向弥合啮齿动物和人类研究之间的差距。MATRR的基础是，非人灵长类动物，特别是猴，在很长一段时间（12-30个月）内表现出一定范围的过量饮酒（3.0 g/kg或12饮酒当量/天），伴随内分泌、肝脏和中枢神经系统（CNS）过程的病理变化。这些纵向设计跨越了从酒精初始到早期酒精暴露到慢性滥用的“饮酒阶段”。对这些组织的需求和质量已经很高，这反映在要求和出版物的数量上。然而，这一资源需要进一步开发，以实现其作为酗酒研究的尖端翻译工具的潜力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Excessive alcohol ingestion, occasionally or chronically, is co-morbid with medical disorders affecting the brain and behavior as well as other organ damage. Much of what is known about risk for and the consequence of heavy alcohol consumption, including mechanisms of organ damage, is derived from rodent studies or retrospective human accounts. The Monkey Alcohol Tissue Research Resource (MATRR) is a unique post-mortem tissue bank to ensure tissue from animals chronically drinking alcohol, as well as their related drinking and genetic information, is available to the wider alcohol research community insuring reduced numbers of animals used in research. The tissue is derived from a standard protocol of ethanol self-administration in three species of monkeys housed at ONPRC (rhesus and cynomolgus) and Wake Forest (vervet). This resource will provide novel data for hypothesis testing relating the risk for and consequences of alcohol consumption and serve to bi-directionally bridge the gap between rodent and human studies. The basis of the MATRR is that non human primates, specifically monkeys, show a range of drinking excessive amounts of alcohol (3.0 g/kg or a 12 drink equivalent/day) over long periods of time (12-30 months) with concomitant pathological changes in endocrine, hepatic and central nervous system (CNS) processes. These longitudinal designs span "stages of drinking" from ethanol-naive to early alcohol exposure to chronic abuse. The demand for, and the quality of, the tissues are already high as reflected in the number of requests and publications. Nevertheless, this resource needs further development in order to fulfill its potential as a cutting edge translational tool in alcoholism research.