TOPICAL MICROBICIDE AGAINST SIV AND CHLAMYDIA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：测试一种潜在的杀菌剂预防艾滋病病毒传播给妇女的效果。 迫切需要这样一种有效的媒介，以应对全球妇女艾滋病毒新感染人数普遍上升的现象。这项建议在体内测试了单月桂酸甘油对防止猴免疫缺陷病毒经阴道传播到恒河猴的有效性。恒河猴是一种高度相关的非人类灵长类动物，HIV的性黏膜传播模型。我们发现，单月桂酸甘油不会改变恒河猴(Macaca Mulatta)的阴道乳杆菌，并且长期使用是安全的。 该项目使用了动物服务和研究服务。 新闻，2010年3月4日：研究人员发现了可以防止艾滋病毒传播的化合物 Http://www.ahc.umn.edu/research/corridors/infectiousdisease/gml/ 出版物： 在本报告所述期间没有。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To test the efficacy of a potential microbicidal agent to prevent transmission of HIV to women. Such an effective agent is urgently needed to combat the predominant rise globally of new HIV infections in women. This proposal tested in vivo the efficacy of glycerol monolaurate to prevent intravaginal transmission of simian immunodeficiency virus to rhesus macaques, a highly relevant nonhuman primate model of sexual mucosal transmission of HIV. We found that glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginallactobacilli and is safe for chronic use. The project used Animal Services and Research Services. News Item, March 4, 2010: Researchers identify compound that could prevent HIV transmission http://www.ahc.umn.edu/research/corridors/infectiousdisease/gml/ PUBLICATIONS: None this reporting period.