EXPANDING WNPRC RESOURCES FOR AIDS-RELATED RESEARCH

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目的：威斯康星州国家灵长类动物研究中心（WNPRC）的SIV项目的主要目标是了解有效的抗免疫缺陷病毒免疫反应的属性，开发新型艾滋病疫苗，并扩大HIV动物模型，包括来自毛里求斯的食蟹猴（Macaca fascicularis）的独特遗传属性。 西太平洋区域委员会正在经历动物饲养严重短缺，这直接影响了艾滋病研究的进展。我们目前的SIV住房设施接近饱和，不足以满足我们的迫切需要。 这项G20赠款提案的主要目标是将现有的标本储存区（与现有的SIV饲养区相邻）改造成三个新的动物饲养室。该项目在本报告期内完成，包括为这些新动物房配备足够的笼子和自动供水系统。这次翻新的完成为WNPRC的SIV计划的扩展和调查人员继续进行突破性研究提供了必要的关键空间。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: The primary objectives of the SIV program at the Wisconsin National Primate Research Center (WNPRC) are to understand the attributes of effective anti-immunodeficiency virus immune responses, develop novel AIDS vaccines, and expand the HIV animal model to include the unique genetic attributes of cynomolgus macaques (Macaca fasicularis) from Mauritius. The WNPRC is experiencing a critical shortage of animal housing which directly affects advances in AIDS research. Our current SIV housing facility was near capacity and will be insufficient for our immediate needs. The primary goal of this G20 grant proposal was to renovate an existing specimen storage area, which is adjacent to the existing SIV housing area, into three new animal housing rooms. The project, completed during this reporting period, included sufficient caging and an automatic watering system to equip these new animal rooms. The completion of this renovation has provided the critical space necessary for the expansion of the SIV program at the WNPRC and for the investigators to continue their ground-breaking research.