EFFECTS OF CIRCUMCISION ON HIV TRANSMISSION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这是一项试验性建议，旨在确定和优化包皮环切和收集恒河猴阴茎活检的程序，以用于SIV/AIDS疫苗研究。一项主要的艾滋病毒疫苗试验于2008年11月结束，其结论是，如果且仅当男性没有接受割礼时，男性在接种疫苗后感染艾滋病毒的风险会增加。因此，科学家们目前有很多猜测和担忧，即为什么一种本应保护人们免受艾滋病毒感染的疫苗，如果他们没有接受割礼，实际上会增加他们的风险。然而，合适的动物模型还没有开发出来，所以我们希望进行初步研究，看看是否可以建立一个将艾滋病毒传播到阴茎的模型。这个为期一年的项目由基本补助金的行政补充提供资金，证明了这是可行的，猕猴的包皮和阴茎与男性的包皮和阴茎足够相似，可以用作包皮环切和艾滋病毒传播的模型。该项目于去年启动并完成，并资助了一个新项目(Minh Dinh，Pi)，以继续进行此类研究，以确定艾滋病毒和SIV进入男性生殖系统的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This was a pilot proposal to determine the feasibility of, and optimize the procedures involved in circumcising and collecting penile biopsies from rhesus macaques for SIV/AIDS vaccine studies. A major HIV vaccine trial ended in November 2008, which concluded that there was an increased risk for men acquiring HIV after being vaccinated, if and only if the males were not circumcised. Thus, there is currently a lot of speculation and concern among scientists as to why a vaccine that is supposed to protect persons from HIV would actually increase the persons' risk if they were not circumcised. However, a suitable animal model has not been developed so we wish to perform pilot studies to see if a model for HIV transmission to the penis can be established. This 1 year project was funded by an administrative supplement to the base grant demonstrated this was feasible, and that the macaque foreskin and penis was sufficiently similar to those of men to use as a model for circumcision and HIV transmission. This project was initiated and completed in the last year and a new project (Minh Dinh, PI) has been funded to continue such studies in determining the mechanisms of HIV and SIV entry into the male reproductive system.