MIDWEST PROGENITOR CELL CONSORTIUM

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目的：将人多能干细胞和体细胞转化为造血干细胞和自我更新的心脏祖细胞。 中西部祖细胞联盟是威斯康星大学麦迪逊分校和明尼苏达大学之间的合作，将作为NHLBI祖细胞生物学联盟的研究中心。目的是通过鉴定导致前-HSC和心脏祖细胞形成的遗传程序和激活谱系限制细胞中的自我更新程序，开发将人类多能干细胞和体细胞转化为造血干细胞（HSC）和自我更新心脏祖细胞的新策略。 该项目使用WNPRC干细胞资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells. The Midwest Progenitor Cell Consortium is a collaboration between the UW-Madison and the University of Minnesota, which will serve as a research hub within the NHLBI's Progenitor Cell Biology Consortium. The goal is to develop new strategies to convert human pluripotent stem and somatic cells into hematopoietic stem cells (HSCs) and self renewing cardiac progenitor cells through identification of genetic program leading to formation of pre-HSCs and cardiac progenitors and activation of self-renewal program in lineage restricted cells. This project uses WNPRC Stem Cell Resources.