Multi-Center Blinded Analysis of XMRV/MLV in Chronic Fatigue Syndrome

东北生物防御中心(NBC)是一个由350名研究人员组成的联合体，涉及28项学术和研究 机构(其中许多机构在大纽约大都市区距离很近)，以及13个美国机构 政府和国际组织。在过去的5年里，NBC的调查人员 表明他们致力于在以下领域和机构边界之间开展合作 研究和培训方案侧重于生物防御和新出现的传染病以及 做好应急准备。生产率的证据包括&gt；160种出版物，15项发明披露，13项 专利申请和5项产品开发许可证。此次续签将包括42名调查人员和 32个研究项目，分为6个科学主题领域：被动免疫疗法(主席：阿图罗 卡萨德瓦尔，爱因斯坦)；疫苗(主席：约翰·罗斯，耶鲁)；诊断学和病原体发现(主席：伊恩 利普金，哥伦比亚)；治疗学(主席：查尔斯·赖斯，洛克菲勒和霍华德·舒曼，哥伦比亚，)；先天 免疫(主席：纽约大学的David Levy和西奈的Adolfo Garcia-Sastre)和微生物致病(主席： Jorge E.Galan，耶鲁，和Jorge Benach，Stony Book)。生物技术和制药合作者是 出现在诊断和病原体发现(安捷伦、阿肯尼、造父变身、Xynostics、454 Life)中 科学)、治疗(普罗塞塔、斯诺登)和被动免疫治疗(再生)主题。这些 产业联系不仅提供智力资本和资源，而且还提供一条将发现从 NBC实验室将成为一个更大的竞技场，在那里他们可以为人类的健康和福利做出贡献。其他内容 实力来自与国家和国际公共卫生机构的关系，这些机构提供了独特的 获得洞察力和临床材料(如诊断样本和PBMC)，使工作能够 而不是以其他方式被追求。核心设施将包括蛋白质表达、动物模型和蛋白质组学。 我们还将投资于发展项目(创新试点项目)和职业发展和 包括个人和团体职业发展奖励的培训计划。作为总部设在 公共卫生学院和国家卫生部，NBC坚定地致力于和实际 对应急准备的认识。

The Northeast Biodefense Center (NBC) is a consortium of >350 investigators in 28 academic and research institutions (many of them in close proximity to one another in the greater NYC metro area), and 13 USbased governmental and international organizations. Over the past 5 years, NBC investigators have demonstrated their commitment to working together across disciplines and institutional boundaries in research and training programs focused on biodefense and emerging infectious diseases as well as emergency preparedness. Evidence of productivity includes >160 publications, 15 invention disclosures, 13 patent applications and 5 licenses for product development. This renewal will comprise 42 investigators and 32 research projects organized into 6 scientific theme areas: Passive Immunotherapeutics (chair: Arturo Casadevall, Einstein); Vaccines (chair: John Rose, Yale); Diagnostics and Pathogen Discovery (chair: Ian Lipkin, Columbia); Therapeutics (chairs: Charles Rice, Rockefeller and Howard Shuman, Columbia,); Innate Immunity (chairs: David Levy, NYU, and Adolfo Garcia-Sastre, Sinai), and Microbial Pathogenesis (chairs: Jorge E. Galan, Yale, and Jorge Benach, Stony Book). Biotechnology and pharmaceutical collaborators are represented in the Diagnostics and Pathogen Discovery (Agilent, Akonni, Cepheid, Xynostics, 454 Life Sciences), Therapeutics (Prosetta, Snowdon), and Passive Immunotherapeutics (Regeneron) themes. These industrial links provide not only intellectual capital and resources but also a path for moving discoveries from NBC laboratories to a larger arena where they can contribute to human health and welfare. Additional strength derives from relationships with national and international public health agencies that provide unique access to insights and clinical materials (such as diagnostic samples and PBMC) that enable work that could not otherwise be pursuec. Core facilities will include Protein Expression, Animal Models, and Proteomics. We will also invest in Developmental Projects (innovative pilot projects) and in Career Development and Training Programs that include individual and group career development awards. As a Center based in a School of Public Health and a State Department of Health, the NBC has a firm commitment to and practical understanding of Emergency Preparedness.