Creating a Developmental Gene Expression Atlas for Rhesus Macaque Brain

当前提案的目标是生成恒河猴大脑中基因表达的神经发育图谱，创建一个独特的公共访问社区资源，详细描述发育调节和功能重要基因的精确细胞水平时空表达模式。了解人类神经系统的发育对于理解正常的发育过程和具有发育成分的人类神经系统疾病至关重要。非人类灵长类动物为研究与人类直接相关的大脑发育提供了有价值的和实验可处理的模型系统。虽然非人类灵长类动物一直是基因组测序项目的主要焦点，但很少有人关注于研究发育或成人大脑中基因表达的详细时空模式。恒河猴大脑发育基因表达图谱将是了解灵长类动物发育过程的极有价值的资源。

The goal of the current proposal is to generate a neurodevelopmental atlas of gene expression in the rhesus macaque brain, creating a unique public access community resource detailing precise cellular level spatiotemporal expression patterns of developmentally regulated and functionally important genes. Understanding of human nervous system development is of critical importance for understanding normal developmental processes and human neurological disorders with developmental components. Non-human primates provide valuable and experimentally tractable model systems for studying brain development with direct relevance to humans. While nonhuman primates have been a major focus for genome sequencing projects, very little focus has been put on studying detailed spatiotemporal patterns of gene expression in the developing or adult brain. A developmental gene expression atlas for the rhesus macaque brain will be an extremely valuable resource for understanding developmental processes in primates.