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Pilot 3 - Developmental Exposure Alcohol Research Center

Pilot 3 - Developmental Exposure Alcohol Research Center
试点 3 - 发育性暴露酒精研究中心
批准号：
8381966
负责人：
Sandra M Mooney
金额：
$2.21万
依托单位：
STATE UNIVERSITY OF NY,BINGHAMTON
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8381966
关键词：
AcuteAdolescenceAffectAgeAmygdaloid structureAnimalsBehaviorBiological ProcessBrainBrain regionCellsCharacteristicsDataDevelopmentDevelopmental ProcessDoseEthanolEtiologyExposure toFetal Alcohol Spectrum DisorderFetal Alcohol SyndromeGenerationsGrowthHippocampus (Brain)Infusion proceduresMedialNeurobiologyNeurologicNeuronsOutcomeOxytocinPlayPrefrontal CortexRoleSocial BehaviorStructureSystemTestingTimealcohol effectalcohol researchbasebehavior testcraniofacialdevelopmental diseaseearly adolescencegastrulationmalemalformationmigrationneuronal survivaloffspringprenatal exposuresocialtranscriptional coactivator p75young adult

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中文摘要
翻译
社会行为受到产前接触乙醇的影响。人们认为杏仁核中的催产素系统 在社会行为中扮演重要角色。我们将检验原肠胚形成期间的急性暴露 （妊娠第7天（G））或在杏仁核神经元产生期间（G14）将导致显著的 社会行为缺陷。动物将在G7或G14给予乙醇。后代将经历社会行为 然后收集大脑用于分析乙醇对杏仁核的影响。这些研究将 提供了与产前暴露于乙醇相关的社会行为缺陷的病因学的有价值的数据 并将开始研究造成这种赤字的机制。
英文摘要
Social behavior is affected by prenatal exposure to ethanol. The oxytocin system in the amygdala is thought to play a major role in social behavior. We will test the hypothesis that acute exposure during gastrulation (gestational day (G) 7) or during the time of generation of amygdala neurons (G14) will result in a significant deficit in social behavior. Animals will be given ethanol on G7 or G14. Offspring will undergo social behavior testing then the brains will be collected for analysis of the effect of ethanol on the amygdala. These studies will provide valuable data on the etiology of the social behavior deficits associated with prenatal exposure to ethanol and will begin to examine the mechanism(s) underlying such deficits.
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会议论文
Model of Fetal Alcohol Spectrum Disorder
  • 批准号：
    9260215
  • 项目类别：
  • 资助金额：
    $37.58万
  • 财政年份：
    2017
  • 负责人：
    Sandra M Mooney
  • 依托单位：
    UNIVERSITY OF MARYLAND BALTIMORE
Nutrient combination to mitigate Fetal Alcohol Spectrum Disorder
Model of Fetal Alcohol Spectrum Disorder
Model of Fetal Alcohol Spectrum Disorder
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