Center for American Indian and Alaska Native Diabetes Translational Research

美国印第安人和阿拉斯加原住民（AI/ANs）被诊断患有糖尿病的可能性是美国普通人群的2.3倍，并且还患有相关的高过早死亡率。科罗拉多丹佛大学（UCD）的研究人员已经做好了独特的准备，可以与人工智能/人工智能社区以及为他们服务的人合作，通过转化研究来解决糖尿病相关的健康差异。作为对RFA DK-10-009的回应，我们提议建立一个P30美洲印第安人和阿拉斯加土著糖尿病转化研究中心（CAIANDTR）。CAIANDTR将在地方，区域和国家范围内提供核心服务和咨询，这些服务和咨询与NIDDK的转化研究议程相关，具体针对AI/AN，但可推广到普通人群的其他部分。我们有四个具体目标。1)提供一个行政结构，促进卓越的转化研究，具体到改善糖尿病相关的健康。包括在这个核心将试点和可行性和丰富的计划; 2）召集资助的UCD教师的研究基地; 3）研究所和工作人员4资源核心（参与;技术;实施，传播和扩散;和可持续性），旨在促进一个多学科，文化接地，以问题为导向的转化研究计划的主要科学和方案的重要性，和4）作为全国其他研究人员寻求与AI/AN社区合作的国家资源核心，以及那些努力在农村和其他种族/少数民族人群中进行糖尿病转化研究的人。需要的问题是不言而喻和迫切的。印度卫生系统已准备好开展糖尿病预防和治疗服务，但寻求循证实践方面的指导，以改善其结果。UCD拥有丰富的研究和技术援助资源，与糖尿病转化研究相关，一般来说，特别是AI/AN。我们在全国范围内深入AI/AN社区，与消费者、供应商、规划者、服务机构、倡导者、政策制定者、项目资助者和其他科学家建立了广泛的合作伙伴关系。但是，要利用这一难得的机会，就需要协调资源，而这些资源通常只能通过诸如30主席这样的机制获得。通过这种方式，我们将解决与糖尿病有关的健康差距，在这个国家，当然，如果不是世界上风险最高的人群。

American Indians and Alaska Natives (AI/ANs) are 2.3 times more likely to be diagnosed with diabetes than others in the U.S. general population-and also to suffer from high rates of related premature mortality. Researchers at the University of Colorado Denver (UCD) are uniquely prepared to collaborate with AI/AN communities and those who serve them in tackling diabetes-related health disparities through translational research. In response to RFA DK-10-009, we propose to establish a P30 Center for American Indian and Alaska Native Diabetes Translational Research (CAIANDTR). CAIANDTR will provide core services and consultation locally, regionally, and nationally in areas relevant to the NIDDK's translational research agenda, specific to Al/ANs but generalizable to other segments of the general population. We have 4 specific aims. 1) Provide an administrative structure that promotes excellence in translational research specific to improving diabetes-related health. Included within this core will be Pilot and Feasibility and Enrichment programs; 2) Convene a Research Base of funded UCD faculty; 3) Institute and staff 4 Resource Cores (Engagement; Technology; Implementation, Dissemination, and Diffusion; and Sustainability) designed to facilitate a multidisciplinary, culturally grounded, problem-oriented translational research program of major scientific and programmatic importance, and 4) Serve as a National Resource Core for other investigators around the country seeking to work with AI/AN communities, as well as to those struggling to pursue diabetes translational research in rural and other racial/ethnic minority populations The timing is ideal for a diabetes translational research center focused on AI/ANs. Issues of need are self-evident and compelling. The Indian health system is primed to institute diabetes prevention and treatment services but seeks guidance in regard to evidence-based practices to improve their outcomes. UCD hosts a rich array of research and technical assistance resources relevant to diabetes translational research, generally, and to AI/ANs specifically. We have a nationwide reach into AI/AN communities, with extensive partnerships with consumers, providers, planners, service agencies, advocates, policy-makers, program funders, and other scientists. But capitalizing on this rare confluence of opportunities requires the coordination of resources not typically available other than through mechanisms such as this P30. In this way we will address the diabetes-related health disparities in a population with the highest risk in this country, certainly, if not the world.