Cell Signaling of Host Defense

由迈克尔·B·费斯勒医学博士领导的国家环境卫生科学研究所内壁研究部呼吸生物学实验室的宿主防御小组自成立以来已进入第六个年头。我们现在已经出版了几篇手稿。自上次年度报告以来的出版物： 1)一份使用蛋白质组学分析来描述巨噬细胞中的酰化(经脂肪酸修饰的)蛋白质的补体，然后验证酰化在其中一种蛋白质--磷脂扰乱酶3的功能中的作用的报告(Merrick BA等人，Mol Cell Proteology 2011) 2)一篇报道人类Toll样受体是主要转录因子p53的靶基因的合作出版物(Menendez D等人，PLoS Genetics 2011)。 3)一篇描述胆固醇转运体ATP结合盒转运体A1在巨噬细胞控制炎症信号中的作用的合作出版物(朱X等，J Lipid Research 2010)。 4)一篇综述文章，描述了通过巨噬细胞质膜的脂类流动如何控制其炎症信号(Fessler MB和Parks JS，J免疫学2011)。 自上次报告以来，我们取得的其他成就包括Fessler博士在2011年戈登动脉粥样硬化研究会议和杜克大学呼吸道生物学论坛上的应邀演讲，以及受邀在2011年秋季肺部研究小组研讨会(佛蒙特州斯托)上发言。费斯勒博士还在2011年美国胸科国际会议上发挥了重要作用，包括组织/主持一次科学研讨会并发表演讲，主持一次海报讨论会议，并在另外两次主题海报会议上担任主持人。此外，Saiful Chowdhury博士，费斯勒实验室的博士后研究员，获得了2011年NIH杰出研究员奖。Fessler博士和他的同事Jim Aloor博士还就一种新型蛋白质提出了临时专利申请，该蛋白质显示出作为炎症反应调节器的潜力(临时专利申请#61/443,491：调节Lrch4活性及其治疗应用(2011年1月17日提交；发明人：Michael B.Fessler，Jim J.Aloor))。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its sixth year at the NIEHS since inception. We have now published several manuscripts. Publications since the last annual report: 1) an report using proteomic analysis to profile the complement of acylated (fatty acid-modified) proteins in the macrophage, and then validating the role of acylation in function of one such protein, phospholipid scramblase 3 (Merrick BA et al., Mol Cell Proteomics 2011) 2) a collaborative publication reporting the human Toll like Receptors are target genes of the master transcription factor p53 (Menendez D et al., PLoS Genetics 2011). 3) a collaborative publication describing the role of the cholesterol transporter ATP Binding Cassette transporter A1 in control of inflammatory signaling by macrophages (Zhu X et al., J Lipid Research 2010). 4) a review article describing how the flow of lipids through the plasma membrane of macrophages controls their inflammatory signaling (Fessler MB and Parks JS, J Immunology 2011). Additional accomplishments since our last report include an invitated talk delivered by Dr. Fessler at the 2011 Gordon Research Conference on Atherosclerosis and at the Duke University Airway Biology Forum, as well as an invitation to speak at the Fall 2011 Pulmonary Research Group Symposium (Stowe, VT). Dr. Fessler also had notable roles at the 2011 American Thoracic International Conference, including organizing/chairing and speaking at a scientific symposium, chairing a poster discussion session, and acting as facilitator at two additional thematic poster sessions. In addition, Dr. Saiful Chowdhury, a postdoctoral fellow in Fessler laboatory, received a 2011 NIH Fellows Award for Research Excellence. Dr. Fessler and his fellow, Dr. Jim Aloor, also established a provisional patent application on a novel protein that shows potential as a regulator of inflammatory responses (Provisional Patent Application #61/443,491: Modulation of Lrch4 activity and Therapeutic Application Thereof (filed January 17, 2011; inventors: Michael B. Fessler, Jim J. Aloor)).