Knockout Mouse Facility

小鼠是与人类关系最密切的实验动物物种，基因敲除技术可以很容易地进行，因此它们是基因敲除实验的首选对象，特别是与人类有关的遗传问题。国家癌症研究所的敲除小鼠设施- Frederick通过同源重组提供具有功能丧失突变的基因工程小鼠模型的生产服务。通过去除某一特定基因并研究小鼠的差异，研究人员可以推断出该特定基因的可能功能。基因敲除小鼠在研究中发挥作用的例子包括研究和模拟不同类型的癌症、肥胖、心脏病、糖尿病、关节炎、药物滥用、焦虑、衰老和帕金森病。基因敲除小鼠还为药物和其他疗法的开发和测试提供了生物学和科学背景。

Mice are the laboratory animal species most closely related to humans in which the knockout technique can be easily performed, so they are a favorite subject for knockout experiments, especially with regard to genetic questions that relate to human The Knockout Mouse facility at the National Cancer Institute - Frederick provides services with the production of genetically engineered mouse models with loss-of-function mutation through homologous recombination. By removing a certain gene and studying the mouse for any resulting differences, researchers can infer the probable function of that particular gene. Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.