COBRE III: Center for Cardiovascular Research

描述（由申请人提供）：根据美国国立卫生研究院PAR-10-196的要求，我们正在提交夏威夷大学（UH）心血管生物医学研究卓越中心（COBRE）的更新申请。约翰·a·伯恩斯医学院（John a . Burns School of Medicine）建立了一个心血管研究中心（OCR），由r01资助的分子心脏病学家拉尔夫·肖赫特（Ralph Shohet）博士领导。在NCRR对我们中心的投资期间，通过前两个资助周期，我们的初级研究人员已经成功地竞争了6个新的r01和3个r21，此外还有NSF， AHA和当地的慈善基金。在过去的五年里，我们在机构和COBRE的支持下招募了两名高级教师和三名初级教师。我们还建立了三个核心实验室，在基因组学、组织病理学和小鼠生理学方面为现代生物医学科学提供重要服务。这些成就实现了心血管COBRE项目的最初目标，即加强医学院和大学的生物医学研究能力，提高我们的研究人员竞争独立校外资金的能力。我们计划在前两个COBRE周期成功的基础上，加强这些核心设施，并将它们置于安全和可持续的财政基础上，以便它们能够继续支持我们机构的生物医学研究。我们的长期目标是继续培训和支持熟练的研究人员骨干，他们的研究将最终减少心脏病和消除夏威夷不同种族群体之间的心血管健康差距，特别是夏威夷原住民。

DESCRIPTION (provided by applicant): We are submitting this renewal application for the Cardiovascular Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health PAR-10-196. The John A. Burns School of Medicine has established a Center for Cardiovascular Research (OCR), led by Dr. Ralph Shohet, an R01-funded molecular cardiologist. During the NCRR's investment in our Center through two previous cycles of funding, our junior investigators have successfully competed for 6 new R01s and 3 R21s, in addition to NSF, AHA, and local philanthropic funding. During the past five years we recruited two senior faculty and 3 junior faculty to our program using a combination of institutional and COBRE support. We have also established three Core laboratories that provide crucial services for modern biomedical science, in Genomics, Histopathology, and Mouse Physiology. These accomplishments fulfill the initial goals of the Cardiovascular COBRE program to strengthen the biomedical research capacity of the Medical School and the University and enhance the ability of our investigators to compete for independent extramural funding. We plan to build upon the success of the first two COBRE cycles by enhancing these core facilities and placing them on a secure and sustainable financial basis, so that they can continue to support biomedical research at our institution. Our long-term goal is to continue to train and support the cadre of skilled researchers whose studies will ultimately reduce heart disease and eliminate cardiovascular health disparities among the diverse ethnic groups of Hawaii, particularly Native Hawaiians. Our two specific aims are: 1. to maintain the growth and enhance the sustainability of Core services, and 2. to develop a pilot project program that will fund the best ideas of our investigators to the point where they are competitive for extramural support. PUBLIC HEALTH RELEVANCE (provided by applicant): With a new campus, new faculty, and renascent administration, our Medical School has embarked on a new direction, developing into a research-centric school that will address the medical problems of our population at a basic level, and provide a new bioscience component to our economy. These Cores provide the capabilities required for modern biomedical science and in some cases are the only such resources in the State.