PATHOGENESIS OF PRIMARY SIVSM LINEAGES IN RHESUS MACAQUES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本项目的主要目的是研究恒河猴不同原始SIVsm谱系的体内发病机制。未在恒河猴体内传代的不同SIVsm原始谱系菌株，显示出不同HIV-1亚型的病毒多样性，毒力可能显著降低。因此，与感染致病的SIVmac239相比，感染原始SIVsm分离株的恒河猴可能更好地概括HIV感染的自然历史。目前正在评估感染六种不同SIVsm原始分离株的恒河猴的SIV特异性免疫反应及其与SIV感染结局的关系。这些研究将为了解疾病进展为艾滋病的病毒和宿主决定因素提供洞察力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The main objective of this project is to study the in vivo pathogenesis of different primary SIVsm lineages in rhesus macaques. Different strains of primary SIVsm lineages that have not undergone passage in rhesus macaques, display the viral diversity of different HIV-1 subtypes and may be significantly less virulent. Thus, infection of rhesus macaques with primary SIVsm isolates may better recapitulate the natural history of HIV infection, as compared to infection with pathogenic SIVmac239 infection. The SIV-specific immune response and its relation to the outcome of SIV infection in rhesus macaques infected with six different lineages of primary SIVsm isolates is being evaluated. These studies will provide insight into the viral and host determinants of disease progression to AIDS.