IN VIVO IMAGING FOR DETECTION OF TRANSPLANTED STEM/PROGENITOR CELLS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 干细胞研究中有效的活体成像技术的一个关键差距是需要提高检测灵敏度，并确保图像可以准确地量化任何给定解剖位置的细胞数量。核医学技术，特别是正电子发射断层扫描(PET)具有比MRI高得多的灵敏度，而且与光学成像不同，光学成像具有类似的灵敏度，可以提供3D定量图像。使用PET成像的结果也可以从动物模型移植到人类身上。总体目标是开发灵敏的体内成像方法，以监测和跟踪移植的人类干细胞和祖细胞，并克服目前促进将这些独特的细胞群体用于再生医学目的的障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A crucial gap for effective in vivo imaging technologies in stem cell research is the need to improve detection sensitivity and to ensure that images can accurately quantify the number of cells at any given anatomical location. Nuclear medicine techniques, especially positron emission tomography (PET) have much higher sensitivity than MRI, and unlike optical imaging, which has similar sensitivity, can provide 3D quantitative images. Outcomes using PET imaging can also be translated from animal models to humans. The overall goal is to develop sensitive in vivo imaging methods to monitor and track transplanted human stem and progenitor cells and overcome current barriers that advance the use of these unique cell populations for regenerative medicine purposes.