MOLECULAR AND GENETIC ADAPTATIONS ASSOCIATED WITH COMPULSIVE COCAINE INTAKE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 可卡因滥用和成瘾仍然是世界范围内的一个主要问题，具有严重的医疗和社会经济后果，并且几乎没有有效的治疗方法来治疗这种大脑疾病。成瘾神经生物学中的一个流行理论是，重复接触可卡因会使奖赏回路中的神经化学和分子发生持续变化，例如改变基因表达。该项目的目标是全面调查中皮质边缘奖励回路内的基因表达失调，可能介导的强迫性可卡因服用，使用非人灵长类动物模型的中度和过量可卡因自我管理。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cocaine abuse and addiction continues to be a major problem worldwide with grave medical and socioeconomic consequences, and few effective therapies exist to treat this brain disorder. A prevailing theory in the neurobiology of addiction is that repeated cocaine exposure imposes persistent neurochemical and molecular changes, e.g. altered gene expression, in the reward circuitry. The goal of this project is to comprehensively investigate gene expression dysregulation within the mesocorticolimbic reward circuit that may mediate compulsive cocaine taking, using a nonhuman primate model of moderate and excessive cocaine self-administration.