DEVELOPMENT SMALL ANIMAL DIGITAL SUBTRACTION ANGIOGRAPHY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 Ming探索了使用几种不同的K发射X射线源（W、Mo、Rh）来改善小动物数字减影血管造影术的对比噪声。K发射体的使用将通过以下方式改善对噪声的对比度：1）K发射体的通量产生在低能量下比Bremstrhalung更有效; 2）检测器磷光体的量子检测效率在较低能量下高得多（检测磷光体必须薄以限制来自光散射的分辨率降级）;以及3）软组织、钙化和碘/钆（潜在的血管造影剂）之间的光电吸收差异在较低能量下增加。 基于模拟结果，Ming增强了我们目前用于小动物数字减影血管造影的微型X射线系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Ming explored the use of several different K emission X-ray sources (W, Mo, Rh) to improve the contrast-to-noise for small animal digital subtraction angiography. Use of a K emitter will improve contrast to noise by: 1) flux production of the K emitters is much more efficient at low energies than Bremstrhalung; 2) the quantum detection efficiency of the detector phosphors is much higher at lower energies (detecting phosphors must be thin to limit resolution degradation from light scatter); and 3) photoelectric absorption differences between soft tissue, calcification and iodine/gadolinium (potential vascular contrast agents) increase at lower energy. Based on simulation results, Ming enhanced our current micro-x-ray system for small animal digital subtraction angiography.