TECHNIQUES FOR T1P-WEIGHTED IMAGING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 磁共振(MR)图像的常规对比度是由1H磁弛豫导出的 组织的特性。纵向磁弛豫(T1)和横向磁弛豫值的变化 松弛(T2)区分健康状态和病理状态。非同寻常的对比 基于旋转标架自旋-晶格驰豫时间t1的机制对 人类乳房病变状态、大鼠早期急性脑缺血、软骨退变 在骨关节炎、创伤后软骨损伤和腰间盘狭窄期间 与退行性间盘疾病有关。此外，功能性T1？成像显示 增强了BOLD信号，并改进了对间接检测到的新陈代谢17O水的反应。这个 这个子项目的目的是开发T1加权成像的技术，强调两者 新的方法和翻译到临床。 新方法 1.通过非共振旋转回波磁化准备来校正B1场的异质性 脉冲序列。 2.利用集成的自旋回波和自旋锁定校正B0和B1场的异质性 磁化准备脉冲序列。 3.集成自旋锁定和平衡梯度回波脉冲的稳态自旋锁定技术 序列设计。 翻译到临床的方法 1.T1？-准备中心重新排序的多梯度回波(平衡和损坏)，用于快速3D T1？加权图像采集。 2.结合部分傅里叶变换和并行成像的k空间图像去模糊捕获算法 缩短了获取时间。 3.使用T1？准备的k空间加权图像对比度(T1？-KWIC)减少成像时间 在k-空间获取期间的径向投影的视图共享。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Conventional contrast in magnetic resonance (MR) images is derived from the 1H magnetic relaxation properties of tissues. Variations in longitudinal magnetic relaxation (T1) and transverse magnetic relaxation (T2) distinguish the healthy and pathological states. An unconventional contrast mechanism based on the rotating frame spin-lattice relaxation time T1¿ has shown sensitivity to the diseased states of the human breast, early acute cerebral ischemia in rats, cartilage degeneration during osteoarthritis, posttraumatic cartilage injury and narrowing of lumbar intervertebral discs associated with degenerative disc disease. In addition, functional T1¿ imaging shows both an augmented BOLD signal and improved response to indirectly detected metabolic 17O water. The purpose of this subproject is to develop techniques for T1¿-weighted imaging emphasizing both novel methods and translation to the clinic. Novel Methods 1. Correction for B1 field heterogeneity by an off-resonance rotary echo magnetization preparation pulse sequence. 2. Correction for B0 and B1 field heterogeneity by an integrated spin echo and spin lock magnetization preparation pulse sequence. 3. Steady-state spin lock techniques by integrated spin lock and balanced gradient echo pulse sequence design. Methods for Translation to the Clinic 1. T1¿-prepared centrically reordered multiple gradient echo (balanced and spoiled) for rapid 3D T1¿-weighted image acquisition. 2. Integrated partial Fourier and parallel imaging k-space acquisition for image blur reduction and reduced acquisition time. 3. Decreased imaging time using T1¿-prepared k-space weighted image contrast (T1¿-KWIC) for view sharing of radial projections during k-space acquisition.