INTRAOPERATIVE OPTICAL IMAGING FOR NEUROSURGICAL GUIDANCE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 手术切除脑肿瘤是脑肿瘤患者接受的最常见的初始治疗。手术切除可以从几个方面使患者受益：例如，它减轻了肿瘤对神经组织的占位效应，并允许对肿瘤进行组织学诊断，这直接影响了后续治疗策略的方向（3）。许多研究表明，积极的手术切除可以提高脑肿瘤患者的生存时间和生活质量。因此，脑肿瘤切除术的目标是最大限度地切除肿瘤，同时最大限度地减少神经损伤。为了实现这一目标，在开颅术中准确识别脑肿瘤的边缘是必要的。本研究旨在开发一种利用光学技术（如调制成像）可视化脑肿瘤边缘的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Surgical removal of brain tumors is the most common initial treatment received by brain tumor patients. Surgical resection can benefit the patients in several ways: for example, it relieves the mass effect of tumor on neurological tissue and allows histological diagnosis of the tumor, which directly affects the direction of follow-up therapeutic strategy (3). Many studies have demonstrated that aggressive surgical resection enhances the survival length and quality of life for brain tumor patients. Therefore, the goal of brain tumor resection procedures is to maximize tumor removal with minimal neurological damage. To achieve this goal accurate intraoperative identification of brain tumor margins during craniotomy is required. This study aims at the development of a means for visualizing brain tumor margins using optical techniques such as Modulated Imaging.