MACROPHAGE FATTY-ACID SYNTHASE DEFICIENCY DECREASES DIET-INDUCED ATHEROSCLEROSIS
MACROPHAGE FATTY-ACID SYNTHASE DEFICIENCY DECREASES DIET-INDUCED ATHEROSCLEROSIS
批准号:
8361454
负责人:
Clay F. Semenkovich
金额:
$0.43万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-01-01 至 2011-12-31
关键词:
AffectApolipoprotein EArterial Fatty StreakAtherosclerosisDietFatty AcidsFatty-acid synthaseFundingGrantLesionMass Spectrum AnalysisMusNational Center for Research ResourcesPrincipal InvestigatorResearchResearch InfrastructureResourcesSourceUnited States National Institutes of Healthbiomedical resourcecostfatty acid metabolismmacrophage
中文摘要
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其它NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
脂肪酸代谢在动脉粥样硬化病变中受到干扰,但它是否影响病变的形成尚不清楚。为了确定脂肪酸合成是否影响动脉粥样硬化,我们灭活了apoE缺陷小鼠巨噬细胞中的脂肪酸合成酶(FAS)。
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Fatty acid metabolism is perturbed in atherosclerotic lesions, but whether it affects lesion formation is unknown. To determine whether fatty acid synthesis affects atherosclerosis, we inactivated fatty-acid synthase (FAS) in macrophages of apoE-deficient mice.
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Lipidation and Vascular Disease
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批准号:10396073
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项目类别:
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资助金额:$39.38万
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财政年份:2021
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负责人:Clay F. Semenkovich
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依托单位:
Lipidation and Vascular Disease
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批准号:10602437
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项目类别:
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资助金额:$39.38万
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财政年份:2021
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负责人:Clay F. Semenkovich
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依托单位:
Lipidation and Vascular Disease
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批准号:10180573
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项目类别:
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资助金额:$39.38万
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财政年份:2021
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负责人:Clay F. Semenkovich
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依托单位:
Diabetes and Related Metabolic Diseases
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批准号:9429380
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资助金额:$1.12万
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财政年份:2017
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负责人:Clay F. Semenkovich
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依托单位:
GLUCOCORTICOID RECEPTOR POST-TRANSLATIONAL MODIFICATIONS IN INSULIN RESISTANCE
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批准号:9980364
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项目类别:
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资助金额:$34.31万
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财政年份:2016
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负责人:Clay F. Semenkovich
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依托单位:
MODULATING PHYSIOLOGIC EFFECTS OF PHOSPHOLIPID METABOLISM IN OBESITY AND DIABETES
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批准号:8885119
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项目类别:
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资助金额:$42.4万
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财政年份:2015
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负责人:Clay F. Semenkovich
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依托单位:
MODULATING PHYSIOLOGIC EFFECTS OF PHOSPHOLIPID METABOLISM IN OBESITY AND DIABETES
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批准号:9221327
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项目类别:
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资助金额:$42.4万
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财政年份:2015
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负责人:Clay F. Semenkovich
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依托单位:
Animal Model Research Core
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批准号:8132691
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项目类别:
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资助金额:$14.53万
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财政年份:2011
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负责人:Clay F. Semenkovich
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依托单位:
OBESITY, ADIPOGENESIS, AND LIPID LIGANDS
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批准号:7855309
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项目类别:
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资助金额:$38.0万
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财政年份:2010
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负责人:Clay F. Semenkovich
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依托单位:
OBESITY, ADIPOGENESIS, AND LIPID LIGANDS
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批准号:8444588
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项目类别:
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资助金额:$30.46万
-
财政年份:2010
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负责人:Clay F. Semenkovich
-
依托单位:
OBESITY, ADIPOGENESIS, AND LIPID LIGANDS
-
批准号:8245176
-
项目类别:
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资助金额:$31.56万
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财政年份:2010
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负责人:Clay F. Semenkovich
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依托单位:
OBESITY, ADIPOGENESIS, AND LIPID LIGANDS
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批准号:8061601
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项目类别:
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资助金额:$31.56万
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财政年份:2010
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负责人:Clay F. Semenkovich
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依托单位:
DE NOVO LIPOGENESIS AND METABOLIC DISEASE
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批准号:8290871
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项目类别:
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资助金额:$33.06万
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财政年份:2007
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负责人:Clay F. Semenkovich
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依托单位:
DE NOVO LIPOGENESIS AND METABOLIC DISEASE
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批准号:8845193
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项目类别:
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资助金额:$33.06万
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财政年份:2007
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负责人:Clay F. Semenkovich
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依托单位:
DE NOVO LIPOGENESIS AND METABOLIC DISEASE
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批准号:8459974
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项目类别:
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资助金额:$31.9万
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财政年份:2007
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负责人:Clay F. Semenkovich
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依托单位:
CHLOROQUINE AND THE METABOLIC SYNDROME
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批准号:7603335
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项目类别:
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资助金额:$0.28万
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财政年份:2007
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负责人:Clay F. Semenkovich
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依托单位:
De Novo Lipogenesis and Metabolic Disease
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批准号:7616691
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项目类别:
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资助金额:$30.54万
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财政年份:2007
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负责人:Clay F. Semenkovich
-
依托单位:
De Novo Lipogenesis and Metabolic Disease
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批准号:7173988
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项目类别:
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资助金额:$31.19万
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财政年份:2007
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负责人:Clay F. Semenkovich
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依托单位:
CHLOROQUINE AND THE METABOLIC SYNDROME
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批准号:7377221
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项目类别:
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资助金额:$1.83万
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财政年份:2006
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负责人:Clay F. Semenkovich
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依托单位:
SCCOR in Metabolic Syndrome and Vascular Disease
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批准号:7622662
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项目类别:
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资助金额:$196.92万
-
财政年份:2006
-
负责人:Clay F. Semenkovich
-
依托单位:
海外基金