D- CHIRO-INOSITOL IS ABSORBED BUT NOT SYNTHESISED IN RODENTS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 D-甲基肌醇(DCI)和品尼醇(1D-3-O-甲基-甲基肌醇)是两种独特的肌醇，据报道它们具有类似胰岛素的特性。含DCI的化合物在常见的实验动物饲料中含量丰富。通过对6m-HCl水解物的GC-MS分析，Purina实验室啮齿动物饲料5001(饲料5001)含有0.23%的总DCI，其中大部分存在于紫花苜蓿和豆粕成分中。相比之下，只观察到了微量的L-肌醇。DCI部分以水溶性非离子形式存在，其中大部分是Pinitol。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. d-chiro-inositol (DCI) and pinitol (1d-3-O-methyl-chiro-inositol) are distinctive inositols reported to possess insulin-mimetic properties. DCI-containing compounds are abundant in common laboratory animal feed. By GC-MS of 6 m-HCl hydrolysates, Purina Laboratory Rodent Diet 5001 (diet 5001) contained 0.23 % total DCI by weight with most found in the lucerne and soya meal components. In contrast, only traces of l-chiro-inositol were observed. The DCI moiety was present in a water-soluble non-ionic form of which most was shown to be pinitol.