DEVELOPMENTAL EFFECTS OF EARLY IRON DEFICIENCY IN RATS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 主要授予标题：早期缺铁的行为，主要PI：Betsy Lozoff，MD 密歇根大学人类生长与发展中心，密歇根州安阿伯 孕激素缺乏和出生后早期缺铁在人类中很常见，并导致行为改变，提示纹状体功能障碍。相反，铁过载已被提出在神经变性中起重要作用。本项目的目的是使用动物模型研究缺铁和铁治疗对发育中的大脑的影响。早期缺铁改变了发育中纹状体的神经化学特征，并导致大鼠纹状体依赖性行为异常。从缺铁和铁充足的大鼠幼仔的纹状体非侵入性地定量脑代谢物，并且将使用9.4T下的1H NMR光谱确定不同剂量的铁补充剂的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Prime grant title: Behavior in Early Iron Deficiency, Prime PI: Betsy Lozoff, MD Center for Human Growth and Development, University of Michigan, Ann Arbor, MI Gestational and early postnatal iron deficiency occurs commonly in humans and results in altered behaviors suggestive of striatal dysfunction. Conversely, iron overload has been proposed to play a significant role in neurodegeneration. The purpose of this project is to investigate the effect of the iron deficiency and iron treatment on the developing brain using an animal model. Early iron deficiency alters the neurochemical profile of the developing striatum and accounts for abnormalities in striatum-dependent behavior in rats. Brain metabolite are non-invasively quantified from striatum of iron-deficient and iron-sufficient rat pups and the effects of different doses of iron supplementation will be determined using 1H NMR spectroscopy at 9.4T.