STRUCTURE FUNCTION RELATIONSHIPS IN POLYSACCHARIDES & POLYSACCHARIDE-BLENDS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项建议的主要重点是了解生物聚合物的结构行为，从而设计新材料，以及利用多糖纤维作为药物分子、营养食品和维生素的控制输送载体。我们已经成功地将姜黄素(营养品)和维生素C等药物分子包裹在IOTA-卡拉胶纤维中，并展示了小分子掺入后IOTA-卡拉胶网络中的堆积变化。这些结果进一步得到流变学、差示扫描量热法研究以及药物分子从卡拉胶网络中的控制释放的证实。这些初步结果清楚地表明，使用食品亲水胶体的新型受控递送载体的开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The main focus this proposal is about understanding the structural behavior of biopolymers leading to the design of new materials as well as utilizing the polysaccharide fibers as control delivery vehicles of Drug molecules, Nutraceutical and Vitamins. We have successfully encapsulated several drug molecules, Curcumin (nutraceutical) and Vitamin- C in the iota-carrageenan fibers and demonstrated the packing changes in the iota-carrageenan network upon the small molecule incorporation. These results are further corroborated by Rheology, Differential Scanning Calorimetry studies as well as control release of drug molecule from the carrageenan network. These preliminary results clearly suggest the development of novel and controlled delivery carriers using food hydrocolloids.