GLYCOVAULT: A BIOINFORMATICS INFRASTRUCTURE FOR GLYCAN PATHWAY ANALYSIS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 Glyco-Vault的主要目的是支持糖生物学家收集和分析有关聚糖的数据的研究，例如在细胞生命周期中其丰度水平的变化以及它们与生物合成过程中作为酶的蛋白质的基因表达水平的相关性。为了支持聚糖生物合成途径的可视化、分析和建模，GlycoVault一直在从各种来源收集数据和知识。传统的生物信息学资源由关系数据库提供，尽管使用本体表示这种知识有其自身的优势。在GlycoVault中，我们利用这两种技术来提供集成的生物信息学基础设施，可以作为最终用户以及其他程序和应用程序的资源。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The principal purpose of Glyco-Vault is to support the research of glycobiologists in collecting and analyzing data about glycans, such as the changes in their abundance level over a cell's life cycle as well as their correlation with gene expression levels for proteins that serve as enzymes in the biosynthetic process. In order to support glycan biosynthesis pathway visualization, analysis and modeling, GlycoVault has been collecting data and knowledge from a variety of sources. Traditional, bioinformatics resources have been provided by relational databases, although representation of this knowledge using ontologies has its own advantages. In GlycoVault, we utilize both technologies to supply an integrated bioinformatics infrastructure that can serve as a resource to both end users as well as other programs and applications.