PROJECT C

项目C：代谢的系统遗传学；Ron Korstanje(Jackson) 小鼠被用作许多新陈代谢特征的模型。数以百计的QTL研究已经被 出版了。然而，这些研究中的大多数都是衡量单一特征的，即使明确的相关性和 多个性状之间存在交互作用。此外，这些研究通常不考虑表观遗传或环境因素。 效果。在代谢特征的系统遗传学方法中，重点是高密度脂蛋白胆固醇水平，我们 结合代谢图谱、RNA转录本测序(RNAseq)、全基因组甲基化图谱、 以及杂交重组近交系(Rix)协同杂交(CC)小鼠对MAP的作图能力 代谢综合征相关性状、肝脏(等位基因特异性)转录本和剪接变异体及其相互作用 标准饮食和富含维生素D的饮食都是如此。

Project C: Systems Genetics of Metabolism; Ron Korstanje (Jackson) The mouse has been used as a model for many metabolic traits. Hundreds of QTL studies have been published. However, most of these studies measure single traits, even though clear correlations and interactions exist for multiple traits. In addition, these studies usually do not look at epigenetic or environmental effects. In a systems genetics approach to metabolic traits, with an emphasis on HDL cholesterol levels, we combine metabolic profiling, sequencing of RNA transcripts (RNAseq), whole-genome methylation mapping, and the mapping power of intercrossed recombinant inbred (RIX) Collaborative Cross (CC) mice to map metabolic syndrome related traits, liver (allele-specific) transcripts and splice variants and their interactions, on both a standard chow diet and a vitamin D enriched diet.