2013 Nucleic Acids Gordon Research Conference

描述（由申请人提供）：本提案要求部分支持将于2013年6月2日至7日在缅因州比德福德的新英格兰大学举行的核酸会议，作为戈登研究会议系列的一部分。戈登核酸研究会议成立于50多年前，从那时起，核酸生物学的基本发现影响了我们对从核酸化学到核酸在几乎所有生物学方面介导反应中的作用等领域的理解。本次会议的广泛和长期目标是通过汇集世界领先的研究人员，创造一个讨论新思想的论坛，促进跨学科的讨论和合作，加强我们对核酸在生物学、人类健康和疾病中的作用的理解。这次会议的具体目标是召集35名主要专家，他们涵盖这一领域的关键和不同领域，共有150名与会者，举行为期五天的会议。2013年核酸GRC会议将重点介绍核酸研究的八个广泛分类领域的最新进展，包括DNA和RNA生物学，生物化学和生物物理学，以突出新兴概念和技术。具体主题包括：基因组完整性；DNA复制;染色质结构与动力学；转录调控和转录后调控；非编码rna;RNA加工及输出；核糖体功能及调控；核酸结构与催化。这一申请的意义在于，戈登研究会议将提供一个论坛，汇集和协同国际研究界的成员专门从事核酸研究的不同领域。例如，过去十年的发现使人们对非编码核酸在细胞中的作用及其对调节核酸生物合成和加工的影响重新感到兴奋。我们将重点鼓励青年科学家，特别是新从事核酸研究的青年科学家参加并出席会议，并在会议日程中安排从提交的摘要中挑选的简短发言时间。这一应用与健康的关系是，演讲和随后的讨论将有助于确定与基础科学和开发利用核酸治疗人类疾病的新策略相关的重要问题。例如，几种核酸疗法是基于在核酸GRC上提出和讨论的发现；其中一些治疗方法目前正在黄斑变性和丙型肝炎的临床试验中。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleic Acids as part of the Gordon Research Conference series to be held June 2 -7, 2013, at the University of New England, Biddeford, Maine. The Gordon Research Conference on Nucleic Acids was established more than 50 years ago and since that time, fundamental discoveries in nucleic acids biology have impacted our understanding in areas ranging from nucleic acid chemistry to the role that nucleic acids play in mediating responses in nearly every facet of biology. The broad and long-term goal of this conference is to create a forum for discussion of new ideas by bringing together the world's leading researchers, to foster cross-disciplinary discussions and collaborations, to enhance our understanding of the role of nucleic acids in biology, human health and disease. The specific aims of this meeting are to convene 35 leading experts that cover critical and diverse areas within this field, with a total of 150 participants, for a five-day meeting. The 2013 meeting of the Nucleic Acids GRC will highlight recent advances among eight broadly classified areas of nucleic acids research that encompass DNA and RNA biology, biochemistry and biophysics with a view toward highlighting emerging concepts and technologies. Specific topics include: Genome Integrity; DNA Replication; Chromatin Structure and Dynamics; Co- and Post-transcriptional Regulation; Non-coding RNAs; RNA Processing and Export; Ribosome Function and Regulation; Nucleic Acid Structure and Catalysis. The significance of this application is that this Gordon Research Conference will provide a forum for bringing together and synergizing members of the international research community specializing in diverse areas of nucleic acids research. For example, discoveries over the past decade have resulted in renewed excitement regarding the role of non-coding nucleic acids in cells and their impact on regulating nucleic acid biosynthesis and processing. We will place an emphasis on encouraging young scientists, especially those newly engaged in nucleic acids research, to attend and present at this meeting, with time specifically allotted in te schedule for short talks selected from submitted abstracts. The health relatedness of this application is that the presentations and ensuing discussions will help define important questions related to basic science and the development of novel strategies for utilization of nucleic acids in the treatment of human disease. For example, several nucleic acid therapeutics are based on discoveries which have been presented and discussed at the Nucleic Acids GRC; some of these therapeutics are currently in clinical trials for the treatment of macular degeneration and hepatitis C.