2012 Signaling by Adhesion Receptor Gordon Research Conference and Frontiers in A

描述（由申请人提供）：申请资金用于支持戈登研究会议（GRC）关于“粘附受体的信号传导”，该会议将于2012年6月24日至29日在缅因州沃特维尔的科尔比学院举行。本次会议将于6月23日至24日与戈登研究研讨会（GRS）一起举行，主题为“粘附和信号传导的前沿”。GRC将涵盖一系列主题，包括整合素到细胞骨架的信号传导，生长，分化和发育途径，钙粘蛋白到细胞骨架的信号传导，生长，分化和发育途径，通过整合素和钙粘蛋白的机械转导，Hippo/YAP途径，细胞粘附受体信号传导的系统生物学方法，以及其他粘附受体信号传导。会议将汇集代表广泛学科、方法和系统的演讲者、讨论者和与会者。会议规模小，气氛非正式，有利于讨论和互动。随附的GRS将为学生和博士后提供一个网络和共享数据的论坛，并将大大加强教育成分。我们对这些受体调控功能的理解取得了重大进展，特别是对信号传导和机械转导的基本生物物理机制的新见解，以及与发育和疾病的联系，使这次会议特别及时。

DESCRIPTION (provided by applicant): Funds are requested to support the Gordon Research Conference (GRC) on "Signaling by Adhesion Receptors" to be held June 24 - 29, 2012 at Colby College, Waterville, ME. This meeting will be held in conjunction with a Gordon Research Seminar (GRS) entitled "Frontiers in Adhesion and Signaling", June 23- 24. The GRC will cover a range of topics including signaling by integrins to cytoskeletal, growth, differentiation and developmental pathways, signaling by cadherins to cytoskeletal, growth, differentiation and developmental pathways, mechanotransduction through integrins and cadherins, the Hippo/YAP pathway, systems biology approaches to signaling by cell adhesion receptors, and signaling by other adhesion receptors. The meeting will bring together speakers, discussants and participants who represent a wide range of disciplines, approaches and systems. The small size of the conference and the informal atmosphere will facilitate discussion and interactions. The accompanying GRS will provide a forum for students and postdoctoral fellows to network and share data, and will greatly strengthen the educational component. Major advances in our understanding of regulatory functions of these receptors, especially new insights into fundamental biophysical mechanisms of signaling and mechanotransduction, and the connection to development and disease make this a particularly timely meeting. PUBLIC HEALTH RELEVANCE: The main goal of this meeting is to accelerate progress by researchers who are studying the biophysics, biochemistry, cell biology, developmental biology and whole organism physiology/pathology of signaling by integrins, and cadherins and other adhesion receptors. Bringing together investigators from these different areas has the potential to catalyze major progress through both cross fertilization, in which ideas and approaches from one field can be applied to the other, and through generalization, in which broad principles become evident. Deeper understanding of the fundamental molecular, cellular and organismal basis for signaling by cell adhesion receptors will lead to improved understanding of birth defects, cardiovascular disease, and cancer among other major problems in human health.