ACR Basic Research Conference

描述（由申请人提供）：十多年来，ACR一直致力于通过其年度基础研究会议促进风湿性疾病科学家和研究人员之间双向交流前沿科学信息，这是一个在ACR年会之前举行的科学研讨会。年会通常吸引超过10，000名与会者，是为研究，教育，病人护理和社会经济问题提供交流思想的论坛的主要机制。它也是传播当前风湿性疾病相关基础研究成果的主要形式。为了强调风湿性和肌肉骨骼疾病发病机制的基础科学原则，ACR在年会中建立了强调基础科学的具体计划。五个会议中的第一个会议将与2010年在格鲁吉亚亚特兰大举行的ACR年度科学会议一起举行，主题是自体免疫中的B细胞：从抗体到免疫调节。这将是一个最先进的会议，由来自美国和国外的杰出科学家组成的著名小组讨论B淋巴细胞（B细胞）的生物学，重点是它们在炎症和自身免疫中的作用。这次会议是由Ann Marshak-Rothstein博士（医学教授）组织的，他是一位世界著名的B细胞生物学家，最近被招募到马萨诸塞州大学医学中心的流变学部门。William St. Clair（医学教授），杜克大学流变学主任，也是杜克自身免疫卓越中心的首席研究员，是免疫耐受网络临床事务副主任，是B细胞和自身免疫性疾病专家。主题已被选定为四个后续会议：2011年将集中在骨重建的调节，骨病理是一个共同的方面，许多风湿性疾病，并发生作为一个后果，许多治疗。2012-2014年的暂定主题列表已被选定，（1）间充质细胞和基质生物学：风湿性疾病中的迁移，侵袭和纤维化。(2)风湿性疾病中先天免疫和适应性免疫之间的界面。(3)免疫调节疾病发病机制中的非编码RNA，（4）风湿性疾病中的脂质介质，（5）免疫介导的炎症性疾病中的细胞应激反应，以及（6）耐受和自身免疫调节中的树突状细胞。

DESCRIPTION (provided by applicant): For over a decade the ACR has been a leader in the effort to facilitate the bidirectional exchange of cutting edge scientific information between scientists and investigators in rheumatic diseases through its annual Basic Research Conference, a scientific symposium that occurs immediately prior to the ACR Annual Meeting at the site of the meeting. The Annual Meeting, which typically attracts more than 10,000 attendees, is the principal mechanism for providing a forum for the exchange of ideas about research, education, patient care and socioeconomic issues. It is also the primary format for disseminating the current basic research findings relevant to rheumatic disorders. In order to emphasize the principles of basic science that underlie the pathogenesis of rheumatic and musculoskeletal diseases, the ACR has built specific programs emphasizing basic science into the Annual Meeting. The topic for the first of the five proposed conferences, to be held in conjunction with the 2010 ACR Annual Scientific Meeting in Atlanta, Georgia, will be B Cells in Autoimmunity: From Antibodies to Immunoregulation. This will be a state-of-the-art conference featuring a prestigious panel of outstanding scientists from the US and abroad to discuss the biology of B-lymphocytes (B-cells) with a focus on their role in inflammation and autoimmunity. The meeting has been organized by Dr. Ann Marshak-Rothstein (Professor of Medicine), a world-renowned B-cell biologist who was recently recruited to the Section of Rheumatology at the University of Massachusetts Medical Center, and Dr. E. William St. Clair (Professor of Medicine), Chief of Rheumatology at Duke University who is also the principal investigator for the Autoimmunity Center of Excellence at Duke and is the Deputy Director of Clinical Affairs for the Immune Tolerance Network and is an expert on B-cells and autoimmune disease. Topics have been chosen for the four subsequent conferences: 2011 will focus on regulation of bone remodeling, bone pathology is a common facet of many rheumatic diseases and occurs as a consequence of many treatments. A list of tentative topics has been chosen for 2012-2014, (1) mesenchymal cells and matrix biology: migration, invasion and fibrosis in rheumatic diseases. (2) the interface between innate and adaptive immunity in rheumatic disease. (3) non-coding RNA in immunoregulation disease pathogenesis, (4) lipid mediators in rheumatic disease, (5) the cellular stress response in immune-mediated inflammatory disease, and (6) dendritic cells in the regulation of tolerance and autoimmunity.