Southern California Women's Interagency HIV Study Consortium

描述（申请人提供）：南加州WIHS联盟（SCWC）的具体目标包括：（1）作为WIHS数据和标本的来源;（2）以对WIHS范围内的科学研究成功至关重要的方式发挥作用;（3）维持队列，包括积极参与批准的子研究以及数据和标本采集;（4）与相关社区团体保持联系;（5）为当地和国家WIHS提供研究设计和分析方面的流行病学专业知识。背景和初步数据：SCWC由4个站点组成：南加州大学医学院/LAC-USC医学中心的中心站点; PROTOTYPES;圣巴巴拉县卫生服务;和夏威夷艾滋病研究联合会。我们的队列是WIHS中第三大队列。在整个WIHS III期间，子研究和其他要求的合规性远高于平均水平。SCWC在WIHS III期间通过以下方式为研究的科学使命做出了贡献：（1）担任19篇同行评审出版物的第一和/或最后作者，最近提交了4篇额外的手稿;（2）在心血管疾病领域发挥领导作用，制定颈动脉内膜增厚研究的初步方案，培训所有WIHS研究中心，以及SCWC的霍华德·霍迪斯（Howard Hodis）博士和温迪·麦克（Wendy Mack）博士正在进行的CIT集中阅读;（3）在基因组学领域发挥领导作用，在利皮尔斯博士的指导下，在南加州大学建立了WIHS DNA生物储存库，由大卫·货车登贝格、丹尼尔·斯特拉姆和大卫·孔蒂博士提供进一步的专业知识。皮尔斯博士还担任WIHS国家基因组学工作组主席，并提出了WIHS在基因组学领域的第一项研究（CROI，2/07）。(4)在AM Levine博士（PI）的专业知识下，在队列中提供艾滋病毒血液学和恶性方面的领导;（5）在Andrea Kovacs，Marek Nowicki和Maria Villacres博士的指导下，在HCV和病毒合并感染领域提供领导。未来计划：（1）我们将继续作为基因组学的领导者，实施和维护WIHS DNA生物库，同时支持WIHS相关基因组学研究的内部和外部研究人员;（2）我们将提供免疫学/炎症方面的专业知识，以推进WIHS的科学议程;（3）我们将为心血管和HPV/癌症议程以及流行病学提供专业知识（4）我们将继续维持SCWC队列。

DESCRIPTION (provided by applicant): SPECIFIC AIMS of Southern California WIHS Consortium (SCWC) include: (1) To serve as a source for WIHS data and specimens; (2) To function in a manner which is critical to the success of WIHS-wide scientific studies; (3) To maintain the cohort, including active participation in approved sub-studies, as well as data and specimen collection; (4) To maintain relations with relevant community groups; (5) To provide epidemiologic expertise in study design and analysis to the local and national WIHS. BACKGROUND AND PRELIMINARY DATA: SCWC is comprised of 4 sites: the central site at USC School of Medicine/LAC-USC Medical Center; PROTOTYPES; Santa Barbara County Health Services; and Hawaii AIDS Research Consortia. Our cohort is the 3rd largest in the WIHS. Compliance with sub-studies and other requirements has been well above average throughout WIHS III. SCWC has contributed to the scientific mission of the study during WIHS III by (1) serving as first and/or last authors on 19 peer reviewed publications, with 4 additional manuscripts recently submitted; (2) providing leadership in the area of cardiovascular disease, with initial protocols for carotid intimal thickening studies, training of all WIHS sites, and on-going central reading of CITs performed by Drs. Howard Hodis and Wendy Mack at SCWC; (3) providing leadership in the area of Genomics, with development of a WIHS DNA Biorepository, housed at USC, under the direction of Dr. Leigh Pearce, with further expertise provided by Drs. David Van Den Berg, Daniel Stram, and David Conti. Dr. Pearce also serves as Chair of the national Genomics Working Group of WIHS, and has presented the first study from the WIHS in the area of genomics (CROI, 2/07). (4) providing leadership hematologic and malignant aspects of HIV in the cohort, with the expertise of Dr. AM Levine (PI); (5) providing leadership in the area of HCV and viral co-infections, under the direction of Drs. Andrea Kovacs, Marek Nowicki, and Maria Villacres. FUTURE PLANS: (1) We will continue as leaders in Genomics, implementing and maintaining the WIHS DNA Biorepository, while supporting internal and external investigators in WIHS-related genomics research; (2) We will provide expertise in immunology/ inflammation, to advance the scientific agenda of the WIHS; (3) We will provide expertise to the cardiovascular and HPV/cancer agendas, and in epidemiology (4) We will continue to maintain the SCWC cohort.