Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

描述（由申请人提供）：申请爱因斯坦内森休克中心（E-NSC）在衰老基础生物学方面的卓越成就，是加强正在进行的研究的自然步骤，加强科学的广泛连续性，并解决这些衰老生物学问题与人类健康的关系。我们已经召集了48名爱因斯坦研究者，13名地区成员和4名国家成员参与正在进行的衰老生物学研究。NSC的目标是：1)加强和扩展爱因斯坦老化研究所正在进行的老化企业的基础生物学，我们将建立3个独特的（在其他NSCs中不存在的）和新颖的（在技术使用上）研究资源核心：a)细胞和组织老化核心（Cuervo），将提供细胞稳态的测量以及蛋白质，脂质，核酸和细胞器的分子修饰；b)健康衰老生理学核心（Barzilai），将对啮齿动物进行复杂的综合代谢研究，以确定“健康衰老”生理学，如体内全身和器官特异性代谢、身体成分和能量平衡、运动、心脏和认知/功能生理学分析；c)衰老核心基因组学和表观基因组学（Vijg），将为研究人员提供来自人类百岁老人和对照的全基因组关联数据，以评估他们感兴趣的基因与人类衰老和疾病的关系，以及用于下一代候选基因区域重测序的序列富集，以及使用先进的高通量技术进行全基因组ONA甲基化分析。2)促进爱因斯坦和其他区域研究机构的衰老生物学研究活动的规划和协调，并通过系列讲座和年度务静会加强项目（行政核心）。3)为新研究者提供支持和合适的环境，包括试点和可行性奖励，指定导师制度，以及共同指导老年生物学研究生课程。4)发展潜在的区域和/或国家资源中心，通过与区域研究者接触，并将核心使用利益扩展到其他NSCs的成员。

DESCRIPTION (provided by applicant): This application for an Einstein Nathan Shock Center (E-NSC) of excellence in the basic biology of aging is a natural step for enhancement of ongoing research, to strengthen the broad continuum of science and to address these biology of aging issues in its relation to human health. We have assembled a cohort of 48 Einstein investigators, 13 Regional members and 4 national members involved in ongoing research in Biology of Aging. The aims of the NSC are:1) To enhance and expand the ongoing basic biology of aging enterprise at the Einstein Institute for Aging Research, we will establish 3 Research Resource Cores that are unique (do not exist in other NSCs) and novel (in their use of technology): a) Cellular and Tissue Aging Core (Cuervo), will provide measurements of cellular homeostasis as well as molecular modifications of protein, lipid, nucleic acids, and organelles; b) Healthy Aging Physiology Core (Barzilai), will perform sophisticated integrative metabolic studies in rodents to determine 'healthy aging' physiology such as in vivo whole body and organ- specific metabolism, body composition and energy balance, exercise, cardiac and cognitive/functional physiology analyses; and, c) Genomics and Epigenomics of Aging Core (Vijg), will provide investigators with whole genome association data from human centenarians and controls to assess their gene of interest in relationship to human aging and diseases as well as sequence enrichment for next generation re-sequencing of candidate gene regions, and genome-wide ONA methylation analysis using advanced high throughput technology. 2) To facilitate the planning and coordination of aging biology research activities at Einstein and other regional research institutions, and program enhancement through a lecture series and a yearly retreat (Administrative Core). 3) To provide support and a suitable environment for new investigators including pilot & feasibility awards, a designated-mentor system, and co-direction of a graduate course in Biology of Aging. 4) To develop potential regional and/or national resource Centers, by reaching out to regional investigators, and extending Core usage benefits to members of other NSCs.