Life-span Evolution of the Capabilities of Rhesus Monkeys

人们对了解早期生活条件和随后生活的作用有着浓厚的兴趣 环境在决定：成人老龄化，健康，社会经济结果，个性和认知方面发挥作用。 同样令人感兴趣的是了解个性和认知对健康，衰老和 社会经济成果。人们还对了解可能的赔偿途径很感兴趣， 在这些领域进行补救和恢复。人类发展的机制植根于生物学、心理学 和环境对于制定促进健康、减少不平等和发展的政策至关重要。 人类潜能的对这些机制的适当研究需要详细的基因生命周期信息， 环境和生物学。如果跨代研究，人们可以更好地研究家庭的影响， 影响，以及环境在改善或加剧初始禀赋中的作用。即使是一项关于 对于一代人内的人类，必要的数据很少;代际数据甚至更零碎。 人类的实验证据也很有限。恒河猴在基因和社会地位上与 人类关于恒河猴及其环境的丰富数据已经收集， 这几代人将用于这个项目。此外，该项目将从各种数据中产生新的数据， 的干预措施。有了这些数据，就有可能研究恒河猴能力的进化，并检查它们的行为能力。 剥夺和补救在生命周期发展中的作用。在动物权利协议规定的范围内， 该项目将设计不利的早期和青少年环境。该项目将利用多个 在恒河猴的五个时间间隔内取样的猴子的生物学（健康）、认知和个性测量 生命周期和执行各种环境干预措施分析这些数据将揭示新的 经验关系和更深层次的，基于生物学的理解的起源和发展， 一种接近人类的动物物种。将使用尖端方法处理这些数据， 对这些恒河猴种群进行为人类种群开发的基因分析。该项目将 分析社会因素如何在动态环境中调节基因表达，特别是哪些基因组 是敏感的社会影响，这些影响是如何转导到分子环境的 细胞，以及固有的遗传特征如何调节社会环境的影响。这些数据将 使用生命周期技能形成的动态经济计量模型进行分析，该模型将指导 人类的政策分析。对恒河猴的分析将作为一个原型， 研究人类发展。

There is substantial interest in understanding the role that early life conditions and subsequent life environments play in determining: adult aging, health, socioeconomic outcomes, personality and cognition. Also of interest is understanding the effects that personality and cognition have on health, aging and socioeconomic outcomes. There is also great interest in understanding possible avenues of compensation, remediation and resilience in these areas. Mechanisms of human development rooted in biology, psychology and the environment are essential to designing policies that promote health, reduce inequality, and develop human potential. A proper study of these mechanisms requires detailed life cycle information on genes, environments and biology. When examined across generations, one can better examine the effects of family influence, and the role of environments in ameliorating or exacerbating initial endowments. Even for a study of humans within a generation, the requisite data are scarce; intergenerational data are even more fragmentary. Experimental evidence for humans is also limited. Rhesus monkeys are genetically and socially similar to humans. Rich data has been collected on rhesus monkeys and their environments, between and across generations, which will be used for this project. Furthermore, this project will generate new data from a variety of interventions. With these data, it is possible to study the evolution of rhesus capabilities and to examine the role of deprivation and remediation in life cycle development. Within limits dictated by animal rights protocols, this project will engineer adverse early and adolescent environments. The project will utilize numerous measures of biology (health), cognition and personality for monkeys sampled over five intervals of the rhesus life cycles and performs a variety of environmental interventions Analyses of these data will reveal new empirical relationships and a deeper, biologically-based understanding of the origins and development of capabilities in an animal species close to humans. Cutting-edge methodology will be used with this data to conduct gene analysis developed for human populations on these rhesus monkey populations. The project will analyze how social factors regulate gene expression in a dynamic setting and in particular which sets of genes are sensitive to social influences, how these influences are transduced into the molecular environment of the cell, and how inherent genetic characteristics might modulate socio-environmental influences. These data will be analyzed using a dynamic econometric model of life cycle skill formation that will guide the formulation of policy analysis for humans. An analysis of rhesus monkeys will serve as a prototype for what is possible in the study of human development.