Mouse/Human Chimera Core

活体模型对于了解病毒性疾病至关重要。缺乏可以展示的动物模型 感染人类免疫缺陷病毒1型(HIV-1)后的病理学阻碍了我们对 与发病机制相关的病毒机制。人/免疫缺陷小鼠的研究进展 嵌合体为研究人类免疫系统及其影响提供了新的模型系统。 艾滋病毒对人体细胞和组织的感染。这些模型涉及不同类型的人的移植 将组织移植到具有几种免疫缺陷之一的小鼠体内。这些缺陷阻止了拒绝 从而为培养人体组织提供体内环境。 CFAR支持的老鼠/人类嵌合体核心旨在帮助加州大学洛杉矶分校的艾滋病调查人员 他们的研究通过提供最先进的人/鼠嵌合体技术和适当的动物 住房设施。该设施将为艾滋病相关的免疫缺陷小鼠提供和安置几种类型的小鼠 在生物安全等级2和生物安全等级2+条件下进行研究。该设施还将提供 咨询嵌合模型的使用，以及构建各种鼠/人嵌合动物 分发给核心用户。

In vivo models are critical to the understanding of viral diseases. The lack of animal models that display pathology following infection with human immunodeficiency virus type 1 (HIV-1) has hindered our knowledge of the viral mechanisms associated with pathogenesis. The development of human/immunodeficient mouse chimeras has provided novel model systems with which to study the human immune system and the effect of HIV infection on human cells and tissues. These models involve transplantation of various types of human tissues into mice who possess one of several types of immune defects. These defects prevent the rejection of the transplanted tissue by the host, thereby providing an in vivo environment for culturing human tissue. The CFAR-supported Mouse/Human Chimera Core is designed to assist AIDS investigators at UCLA with their research by providing state-of-the-art human/mouse chimera technologies and appropriate animal housing facilities. This facility will supply and house several types of immunodeficient mice for AIDS-related research under both Biosafety Level 2 and Biosafety Level 2+ conditions. This facility will also provide consultation on the use of chimeric models, as well as construct various mouse/human chimeric animals for distribution to Core users.