Acute and Chronic In vivo Effects of Engineered Nanomaterials

该研究项目的重点是通过吸入途径体内暴露后，纳米颗粒的物理化学特性在与细胞，细胞器和器官相互作用中的作用。在第一年，我们将评估三种选定的纳米颗粒在三种不同的物理化学状态下的生物活性和毒性。 我们研究的一个重要目标是评估吸入纳米颗粒的急性与慢性毒性。我们建议通过吸入铈、镍和银纳米颗粒来比较实验动物的急性和慢性毒性。这些具有商业重要性的纳米材料（以及联合体选择的其他纳米材料）将在这些吸入研究中动态生成。仅鼻子曝光系统已经构建，纳米粒子生成系统几乎完成（截至2/11）。已完成的任务包括： 1.完全氧化老化的纳米颗粒的炉系统的测试 2.动物舍设施老化系统的构建 3.纳米粒子生成测试材料的排序 4.招募一名接触评估学生参与其硕士论文的研究

This research project focuses on the role of physical-chemical characteristics of nanoparticles in their interactions with cells, organelles, and organs after in vivo exposure via the inhalation route. During the first year, we will assess the biokinetics and toxicity of 3 selected nanoparticles under three different physical-chemical states. An important goal of our research will be the evaluation of acute vs. chronic toxicity of inhaled nanoparticles. We propose to compare the acute and chronic toxicity in test animals exposed by inhalation to cerium, nickel, and silver nanoparticles. Each of these commercially-important nanomaterials (and other Consortium-selected nanomaterials) will be dynamically generated for these inhalation studies. The nose-only exposure system has been constructed and the nanoparticle generation system is almost complete (as of 2/11). Tasks completed include: 1. testing of furnace system to fully oxidize aged nanoparticles 2. construction ofthe aging system in the animal housing facility 3. ordering of test material for nanoparticle generation 4. recruitment of an exposure assessment student to participate in the research for his Master's thesis