Improving Antiretroviral Management for HIV

描述(由申请人提供)：本次K24续展申请的目的是允许申请人继续指导在临床艾滋病毒研究领域寻求职业生涯的学员。这项申请将提供继续利用正在进行和计划中的临床研究的机会，通过UCSD AVRC、加州协作治疗小组(CCTG)和CFAR综合临床系统网络(CNICs)指导传染病研究员、初级教师和研究生参与与艾滋病毒相关的临床研究项目，并继续扩大申请者参与UCSD临床研究培训计划的范围。目标中概述的研究为深入指导以及调查艾滋病毒管理和发病机制中及时和重要的科学问题提供了机会。对于每个目标和次级目标，一名受训者是研究的主要负责人：受训者从一开始就与申请者合作发展研究，并将参与方案制定、研究执行、统计分析、结果解释、陈述和公布结果的各个方面。所有主要研究都得到了资助(被辅导者参与了赠款编写过程)，对于实验室分目标，受训者参加了最近提交的赠款申请。 指导的目标将通过两个科学目标的实施来实现，其中包括几个临床研究。具体目标1：分析CNICs队列数据，以评估抗逆转录病毒(ARV)暴露和由此产生的病毒学和耐药性结果的趋势，包括妇女和非裔美国人之间的结果差异。临床研究：CNICs 002，CNICs 019加上新的CNICs概念提案正在开发中。具体目的2：研究提高对抗逆转录病毒药物的依从性和减少高危行为的技术和行为方法，以潜在地减少艾滋病毒感染者的传播。临床研究：CCTG 592和正在开发的CCTG新研究。 该项目的目标是使首席调查员能够继续指导在临床艾滋病毒调查方面寻求职业生涯的受训人员。这项申请将提供继续利用正在进行和计划中的临床研究的机会，通过UCSD AVRC、加州协作治疗小组(CCTG)和CFAR综合临床系统网络(CNICs)指导传染病研究员、初级教师和研究生参与与艾滋病毒相关的临床研究项目。最终，该项目将有助于确保下一代科学家能够应对改善艾滋病毒感染者的科学和治疗方面的挑战。

DESCRIPTION (provided by applicant): The goal of this K24 renewal application is to allow the applicant to continue to mentor trainees pursuing a career in clinical HIV investigation. This application would provide continued opportunities to utilize ongoing and planned clinical studies to mentor Infectious Disease fellows, junior faculty and graduate students in HIV related clinical research projects through the UCSD AVRC, the California Collaborative Treatment Group (CCTG) and the CFAR Network of Integrated Clinical Systems (CNICS) and to continue to expand the applicant's participation in the UCSD training programs for clinical research. The studies outlined in the aims provide opportunities for in-depth mentoring as well as investigation of timely and important scientific questions in HIV management and pathogenesis. For each of the aims and sub-aims, a mentee is the primary leader of the study: trainees have worked with the applicant to develop the studies from the inception and will participate in every aspect of protocol development, study execution, statistical analyses, results interpretation, presentation and publication of the results. All of the main studies are funded (mentees participated in the grant writing process) and for laboratory sub-aims, trainees have participated in recently submitted grant applications. The goal of mentoring will be achieved through the conduct of 2 scientific aims which incorporate several clinical studies. SPECIFIC AIM 1: To analyze CNICS cohort data to evaluate trends in antiretroviral (ARV) exposure and resultant virologic and resistance outcomes including disparities in outcome among women and African Americans. Clinical Studies: CNICS 002, CNICS 019 plus new CNICS concept proposal in development. SPECIFIC AIM 2: To investigate technologic and behavioral methodologies which improve adherence to ARV and reduce high-risk behavior in order to potentially reduce transmission from HIV- infected subjects. Clinical studies: CCTG 592 and new CCTG studies in development. The goal of this project is to allow the Principal Investigator to continue to mentor trainees pursuing a career in clinical HIV investigation. This application would provide continued opportunities to utilize ongoing and planned clinical studies to mentor Infectious Disease fellows, junior faculty and graduate students in HIV related clinical research projects through the UCSD AVRC, the California Collaborative Treatment Group (CCTG) and the CFAR Network of Integrated Clinical Systems (CNICS). Ultimately, the project would help to ensure that the next generation of scientists is available to meet the challenges of improving science and treatment of HIV infected patients.