Data Management and Biostatistics

有有限的知识，利什曼病在西非，包括环境因素的影响， 疾病，载体唾液在利什曼病中的作用以及其他病原体在这种疾病发展中的作用 被忽视的疾病最近在马里和加纳进行的研究使我们能够制定更全面的 提出了新的假说，以加深我们对传播和发展的认识 皮肤利什曼病在该领域的目的是证实新的方法来预防和治疗这一点， 被忽视的疾病本提案的主要具体目的是：了解免疫相关性 流行区个体对传播媒介唾液蛋白的反应 利什曼病以及重要的是，这些免疫反应如何通过与丝虫的共同感染来调节 沃尔姆斯这些研究结果将有助于指导唾液腺疫苗的开发 proteins.行政核心的长期目标是： 为每个有关机构提供行政管理，2]在与卫生有关的行政问题上提供领导 研究，和3]促进个人培训（能力建设），以确保自我维持 与其他热带医学研究中心合作开展被忽视的热带疾病的研究和网络。更 具体而言，行政核心将1]跟踪每个国家的科学进展和成就， 个别项目和核心; 2]确定并确保不同现场的相关研究的协调 3]确保遵守IRB和其他监管机构对人体研究的规定 4]制定行政指引，以界定调查员的责任，并确保 负责管理为这些研究提供的资金。 相关性（参见说明）： 该提案与公共健康相关，将有助于开发潜在的新疫苗 皮肤利什曼病是许多贫穷国家的地方病。

There is limited knowledge of leishmaniasis in West Africa including the environmental factors affecfing this disease, the role of vector saliva in leishmaniasis and the role of other pathogens in the development of this neglected disease. Recent studies in Mali and Ghana enabled us to formulate more comprehensive quesfions and propose new hypothesis to increase our understanding of the transmission and development of cutaneous leishmaniasis in the field with the objective to idenfify novel ways to prevent and treat this neglected disease. The major specific aim of this proposal is to: understand the association of immune responses of individuals living in endemic areas to vector salivary proteins in the development of leishmaniasis and importantly, how these immune responses may be modulated by co-infecfions with filarial worms. Findings of these study will contribute to guide vaccine development based on salivary gland proteins. The long-term objectives of the Administrative Core are to: 1] develop expertise in research administration for each institution involved, 2] provide leadership on administrative issues related to health research, and 3] to contribute in the training of individuals (capacity building) to ensure self-sustaining research and networks on neglected tropical diseases with other Tropical Medicine Research Center. More specifically, the administrative core will 1] Track scientific progress and accomplishments for each of the individual projects and cores; 2] Identify and ensure the coordinafion of related studies at different field sites and laboratories; 3] Ensure compliance with IRBs and other regulatory authorities for studies of human subjects; 4] Develop administrative guidelines to define the responsibilifies of investigators, and to ensure the responsible management of funds provided for these studies. RELEVANCE (See instructions): This proposal is relevant to publich health at it will contribute to the development of a potenfial new vaccine against cutaneous leishmaniasis, which is endemic in many poor countries.