DTS Imaging with a Digitally Addressable X-Ray Source (DAXS)

描述（由申请人提供）：使用数字可寻址X射线源（DAXS）的三维成像摘要4-D X射线成像将为涉及造影剂注射或解剖运动的成像程序提供强大的工具。在这项研究中，我们建议开发和研究一个4-D X射线成像系统的基础上，数字断层合成（XTS）和数字可寻址的X射线源（DAXS）。DAXS允许在平面X射线面板上的任何数字选择位置生成X射线。这将使我们能够设计和建造一个不含运动部件的固定式制冷系统。由于消除了物理移动部件，扫描速度可以大大提高，从而允许4-D成像，利用该4-D成像，可以对移动解剖结构或注射的造影剂的3-D图像进行成像和监测。DAXS的使用还允许X射线源以2-D图案进行数字移位，从而更有效地模糊焦平面外的物体和更好的平面内物体的对比度。拟议的研究包括两个主要部分，在两个不同的地点进行：Stellarray Inc.，Stellar Micro Devices，Inc.的子公司(SMD)在奥斯汀，得克萨斯州和数字成像研究实验室（DIRL）在美国。德克萨斯M。D.德克萨斯州休斯顿的安德森癌症中心（MDACC）。两个网站的紧密联系鼓励积极的合作和互动。在这次学术界与工业界的合作中，DAXS技术将在SMD开发，并提供给MDACC-DIRL，以实施和研究用于4-D成像的可重构技术。将研究和优化操作参数和图像质量指标。将进行体模实验，以证明和验证所提出的4-D X射线成像技术。在该合作中，每个研究中心将有一名单独的主要研究者（PI）。MDACC PI还将作为联系人和协调PI。 公共卫生相关性：4-D X射线成像将为涉及造影剂注射或解剖运动的成像程序提供强大的工具。在这项研究中，我们建议开发和研究一个4-D X射线成像系统的基础上，数字断层合成（XTS）和数字可寻址的X射线源（DAXS）。DAXS允许在平面X射线面板上的任何数字选择位置生成X射线。这将使我们能够设计和建造一个不含运动部件的固定式制冷系统。由于消除了物理移动部件，扫描速度可以大大提高，从而允许4-D成像，利用该4-D成像，可以对移动解剖结构或注射的造影剂的3-D图像进行成像和监测。DAXS的使用还允许X射线源以2-D图案进行数字移位，从而更有效地模糊焦平面外的物体和更好的平面内物体的对比度。拟议的研究包括两个主要部分，在两个不同的地点进行：Stellarray Inc.，Stellar Micro Devices，Inc.的子公司(SMD)在奥斯汀，得克萨斯州和数字成像研究实验室（DIRL）在美国。德克萨斯M。D.德克萨斯州休斯顿的安德森癌症中心（MDACC）。两个网站的紧密联系鼓励积极的合作和互动。在这次学术界与工业界的合作中，DAXS技术将在SMD开发，并提供给MDACC-DIRL，以实施和研究用于4-D成像的可重构技术。将研究和优化操作参数和图像质量指标。将进行体模实验，以证明和验证所提出的4-D X射线成像技术。在该合作中，每个研究中心将有一名单独的主要研究者（PI）。MDACC PI还将作为联系人和协调PI。

DESCRIPTION (provided by applicant): DTS imaging with a Digitally Addressable X-ray Source (DAXS) Abstract 4-D x-ray imaging would provide a powerful tool for imaging procedures involving contrast injection or anatomical motions. In this research, we propose to develop and investigate a 4-D x-ray imaging system based on digital tomosynthesis (DTS) and a digitally addressable x-ray source (DAXS). The DAXS allows x-rays to be generated at any digitally selected location on a flat x-ray panel. This would enable us to design and construct a stationary DTS system that contains no moving parts. Due to the elimination of physically moving parts, the scan speed can be substantially increased, thus allowing for 4-D imaging, with which 3-D images of moving anatomy or injected contrast materials can be imaged and monitored. The use of a DAXS also allows the x-ray source to be digitally shifted with a 2-D pattern, leading to more effective blurring of the out of focal plane objects and better contrast of the in plane objects. The proposed research consists of two major parts carried out at two different sites: Stellarray Inc., a subsidiary of Stellar Micro Devices, Inc. (SMD) at Austin, TX and the Digital Imaging Research Laboratory (DIRL) at the U. of Texas M. D. Anderson Cancer Center (MDACC) at Houston, TX. The closeness of the two sites encourages active collaboration and interaction. In this Academic-Industry collaboration, the DAXS technology will be developed at SMD and provided to MDACC-DIRL to implement and investigate the DTS techniques for 4-D imaging. Operation parameters and image quality metrics will be investigated and optimized. Phantom experiments will be performed to demonstrate and validate the proposed 4-D x-ray imaging techniques. In this collaboration, there will be a separate Principal Investigator (PI) at each site. The MDACC PI will also serve as the contact and coordinating PI. PUBLIC HEALTH RELEVANCE: 4-D x-ray imaging would provide a powerful tool for imaging procedures involving contrast injection or anatomical motions. In this research, we propose to develop and investigate a 4-D x-ray imaging system based on digital tomosynthesis (DTS) and a digitally addressable x-ray source (DAXS). The DAXS allows x-rays to be generated at any digitally selected location on a flat x-ray panel. This would enable us to design and construct a stationary DTS system that contains no moving parts. Due to the elimination of physically moving parts, the scan speed can be substantially increased, thus allowing for 4-D imaging, with which 3-D images of moving anatomy or injected contrast materials can be imaged and monitored. The use of a DAXS also allows the x-ray source to be digitally shifted with a 2-D pattern, leading to more effective blurring of the out of focal plane objects and better contrast of the in plane objects. The proposed research consists of two major parts carried out at two different sites: Stellarray Inc., a subsidiary of Stellar Micro Devices, Inc. (SMD) at Austin, TX and the Digital Imaging Research Laboratory (DIRL) at the U. of Texas M. D. Anderson Cancer Center (MDACC) at Houston, TX. The closeness of the two sites encourages active collaboration and interaction. In this Academic-Industry collaboration, the DAXS technology will be developed at SMD and provided to MDACC-DIRL to implement and investigate the DTS techniques for 4-D imaging. Operation parameters and image quality metrics will be investigated and optimized. Phantom experiments will be performed to demonstrate and validate the proposed 4-D x-ray imaging techniques. In this collaboration, there will be a separate Principal Investigator (PI) at each site. The MDACC PI will also serve as the contact and coordinating PI.