Nutritional Epidemiology of Cancer Education and Career Development Program

摘要 这是第二次也是最后一次重新提交，为R25教育项目--癌症营养流行病学--寻求更新资金。之前的审查总结认为，“这是一个非常强大和独特的项目。斯坦普费尔博士似乎解决了之前申请中提出的大部分问题。这是一个杰出的项目。”最初的建议是在NCI培训科的鼓励和建议下提交的。通过扩大教育和培训计划来推进营养研究是国家癌症研究所癌症预防部门的高度优先事项。该计划包括提供持续的领导力、专心的教师时间、明确的专业课程、跨学科的研究环境，以及为每个受训人员提供两名(或更多)导师。这一跨学科，但有重点的计划是基于营养学和流行病学的接口。它由Meir Stampfer博士领导，Walter Willett博士担任联合首席调查员，Edward Giovannucci博士担任教育主任，Stephanie Smith-Warner博士担任副教育主任，Lorelei Mucci博士也加入其中。最终目标是培训研究人员发现改变饮食可以降低癌症风险和负担的新方法。该计划现已进入第六个年头(通过免费延期)，已经建立了坚实的成就记录。它借鉴了哈佛大学公共卫生学院流行病学和营养系的丰富其他资源，该学院长期以来一直是公认的流行病学方法、癌症流行病学和营养流行病学的教学和实践培训中心。这一教育计划还利用了达纳-法伯/哈佛癌症中心(DH/HCC)内的各种研究机会，该中心是一个矩阵癌症中心，代表着七个哈佛附属机构的癌症研究。R25借鉴了饮食和癌症领域的重大发展，例如创建了三个由超过25万名男性和女性组成的大型队列，并对其进行了长达28年的重复饮食措施的跟踪调查。通过这项培训拨款，我们汇集了现有的各种要素，并创建了新的要素，以在癌症营养流行病学方面建立一个连贯和有重点的跨学科计划。癌症营养流行病学计划提供了一个独特的利基市场，同时与其他培训赠款相辅相成，协同作用，以健全的生物学为基础，为癌症预防和控制营造强有力的环境。这一新项目在吸引优秀候选人方面已经取得了显著的成功。完成该项目的学员一致在这一领域开始了有前途的职业生涯。

Abstract This is the second and final resubmission to seek renewal of funding for the R25 education program, Nutritional Epidemiology of Cancer. The previous review summary concluded that "This is a very strong and unique program. Dr. Stampfer appears to have addressed most of the problems raised in the earlier application. This is an outstanding program." The original proposal was submitted with the encouragement and advice of the NCI Training Branch. Advancing nutrition research through expanded education and training programs is a high priority of the Division of Cancer Prevention at the National Cancer Institute. This program includes provision of sustained leadership, dedicated faculty time, a well-defined specialized curriculum, interdisciplinary research environments, and two (or more) mentors for each trainee. This interdisciplinary, yet focused, program is based on the interface of nutrition and epidemiology. It is led by Dr. Meir Stampfer, with Dr. Walter Willett as co-Principal Investigator, Dr. Edward Giovannucci as Education Director and Dr. Stephanie Smith-Warner as Associate Education Director, and addition of Dr. Lorelei Mucci. The ultimate goal is to train researchers to discover new ways in which changes in diet can reduce the risk and burden of cancer. The program, now in its sixth year (through a no-cost extension), already has established a solid record of achievement. It has drawn on the wealth of other resources from the Departments of Epidemiology and Nutrition at the Harvard School of Public Health, which has long been a recognized center for didactic and practical training in epidemiologic methods, cancer epidemiology in general, and nutritional epidemiology. This educational program also draws on diverse research opportunities within the Dana-Farber/Harvard Cancer Center (DH/HCC), a matrix cancer center representing cancer research across seven Harvard-affiliated institutions. The R25 draws upon major developments in the area of diet and cancer such as the creation of three large cohorts comprising over 250,000 men and women followed for as long as 28 years with repeated measures of diet. Through this training grant, we have brought together the various elements already in place, and created new elements to build a coherent and focused interdisciplinary program in the nutritional epidemiology of cancer. The Nutritional Epidemiology of Cancer program provides a unique niche, while being complementary and synergistic with the other training grants in order to foster a strong environment, based on sound biology, for cancer prevention and control. This new program has already demonstrated remarkable success in attracting outstanding candidates. Trainees who have completed the program have uniformly embarked on promising careers in this area.