Vascular Biology Training Grant

描述(申请人提供)：血管生物学的研究对我们预防、监测和治疗心血管疾病的方式产生了显著的变化。在过去的50年里，患者护理发生了变化，预期寿命增加，血管问题患者的生活质量得到改善。正是通过对下一代的培训，我们取得了这些成就，也正是通过培训，我们将继续在预防和保健方面取得更多改进。本申请要求提供资金，继续对研究生和博士后进行血管生物学方面的跨学科培训。我们的目标尤其是培养能够：(1)“会说”多种语言(新陈代谢组学、病理学、分子生物学、基因组学和生物数学)、(2)整合信息和思考(3)解决实际临床问题的科学家。为了实现这些目标，我们开发了一种多导师方法，创新的教学内容，并在培训的结构中融入了互动的医学接触。加州大学洛杉矶分校拥有大量跨学科小组，他们的研究重点是血管生物学。该集团包括27个实验室，目前为124名研究生和博士后研究员提供培训。正是这个社区构成了为下一代血管生物学研究人员提供独特培训计划的支柱。作为洛杉矶唯一的血管生物学培训基金和加州四分之一的培训基金，自2002年以来，我们已经培训了28名研究生和博士后研究员。在该计划期间，这些机构已经出版了101份同行评议的出版物，其中9份已经在全国各地的行业和大学中发展了独立的研究小组。此外，与培训计划相关的活动促进了小组之间的互动，加强了合作活动。平均有10份同行评议的出版物表明，每年有两个或更多的实验室参加。在这里，我们要求每年为7名博士后和3名博士后研究员提供资金，其中每年将有2-3名新的研究生和1或2名博士后研究员进入该项目。我们的目标也是积极寻求和促进对代表不足的少数群体的培训和参与(自2002年以来，我们有21%的少数群体受训人员)。该项目的一个重要目标是走在血管生物学教育创新的前沿，强调研究、诚信和伦理。在目前的更新中，我们建议实施若干新战略，以实现这些目标，并进一步提高少数群体的参与和血管研究培训的质量。这一培训计划的成功激发了医学院、文学与科学学院和加州大学洛杉矶分校研究生部的热情，所有这些都承诺为VBTP开发的活动提供额外的机构支持。

DESCRIPTION (provided by applicant): Research in vascular biology has been responsible for remarkable changes in how we prevent, monitor and treat cardiovascular disease. The last fifty years have witnessed a transformation in patient care, increase in life expectancy and improvement in the quality of lives of those afflicted with vascular problems. It is through training of the next generation that we have made these achievements and it is through training that we will continue to make additional improvements in prevention and health care. The present application request funds to continue the interdisciplinary training of graduate students and post-doctoral fellows in vascular biology. In particular we aim at developing scientists who can: (1) "speak" various languages (metabolomics, pathology, molecular biology, genomics, and biomathematics), (2) integrate information and think towards (3) solving real clinical problems. To achieve these goals we have developed a multi-mentorship approach, novel didactic components and incorporated an interactive exposure to medicine into the structure of the training. UCLA houses a tremendous resource of interdisciplinary groups whose research focuses in vascular biology. The group includes 27 laboratories that currently offer training to 124 graduate students and post-doctoral fellows. It is this community that constitutes the pillars of a unique training program for the next generation of investigators in vascular biology. Being the only Vascular Biology Training grant in Los Angeles and one in four in California, we have trained 28 graduate students and post-doctoral fellows since 2002. These have produced 101 peer-reviewed publications while in the program and 9 have progressed to develop independent research groups in industry and universities across the nation. Furthermore, the activities associated with the training program have catalyzed interactions between groups intensifying collaborative activities. On the average 10 peer reviewed publications show the participation of two or more laboratories each year. Here, we request funding for 7 pre and 3 post-doctoral fellows / year, in which 2-3 new graduate students and either 1 or 2 post-doctoral fellows will enter the program each year. It is also our goal to actively seek and promote training and engagement of underrepresented minority groups (since 2002 we have a 21% minority trainee representation). It is an important objective of this program to be at the forefront of innovation in vascular biology education with strong emphasis in research integrity and ethics. In this current renewal we proposed the implementation of several new strategies to attain these goals and further improve the participation of minorities and the quality of training in vascular research. The success of this training program has engendered enthusiasm by the School of Medicine, College of Letters and Sciences and the Graduate Division at UCLA all of which have committed to provide additional institutional support towards activities developed by the VBTP.