Training Program in Cancer Biology

这项提案要求继续为我们的癌症生物学培训计划提供资金。我们要求继续为6名博士后实习生和4名博士后实习生提供资金，并为1名系统生物学博士后实习生提供资金，这是在上一个供资周期中通过这笔赠款的一项补充资金试行的。 该项目即将进入第10个年头。该项目集中培训癌症生物学领域的博士后和博士后实习生，并提供实验方法的技能，使他们能够成为具有批判性、创造性和独立的科学家。培训不仅侧重于与癌症发生、发展和转移有关的生物学问题，而且还侧重于使用有机化学、纳米技术和系统生物学的跨学科方法，并包括接触与癌症诊断和治疗有关的临床问题。所有教员都在维克森林大学健康科学的癌症生物学系有初级或交叉任命。培训计划的特点包括广泛的指导和评估过程以及职业发展活动。该培训计划通过以下方式实现国家癌症研究所的目标：(1)培养有能力在其研究生涯中专注于癌症问题的研究人员；(2)提供跨越化学-物理-生物界面的培训；(3)强调基础科学与癌症患者的临床问题之间的联系。 培训计划在过去的两个资助周期中取得了显著的成功(1)成功地招募了参加培训计划并成功完成培训计划的少数族裔学员；(2)在癌症研究的新领域进行了跨学科培训；(3)申请者的数量和质量、他们的生产力和他们的成就稳步上升。 这项培训计划包括一个完全修订和重新设计的博士后培训计划，该计划回应了最近的批评，并将加强我们录取高质量申请者的能力。

This proposal requests continued funding for our Training Program in Cancer Biology. We are requesting continuation of funding for six predoctoral Ph.D. trainees and 4 postdoctoral trainees, as well as funding for one postdoctoral trainee in systems biology, which was piloted in the previous funding cycle through a supplement to this grant. The program is entering its 10th year. The program intensively trains pre- and postdoctoral trainees in the field of cancer biology and provides the skills in experimental approaches so that they can become critical, creative, and independent scientists. Training includes a focus not only on biological relevant issues to cancer initiation, progression and metastases, but also on transdisciplinary approaches using organic chemistry, nanotechnology and systems biology, and includes exposure to clinical issues surrounding cancer diagnosis and treatment. All faculty preceptors have primary or cross appointments in the Department of Cancer Biology of Wake Forest University Health Sciences. Features of the training program include an extensive mentoring and evaluation process and career development activities. This training program addresses the goals of the National Cancer Institute by (1) producing investigators equipped to focus on the cancer problem in their research careers; (2) providing training spanning the chemical- and physical- biological interfaces; (3) emphasizing links between basic science and the clinical problems of patients with cancer. The training program achieved notable successes during the past two funding cycles (1) successful recruitment of minority trainees who entered and successfully completed the training program; (2) cross disciplinary training in new areas of cancer research; (3) a steady rise in the number and quality of applicants, their productivity and their achievements. This training proposal includes an entirely revised and reengineered postdoctoral training program that is responsive to the recent critique and will strengthen our ability to matriculate top quality applicants to our program.