Predoctoral Training in the Pharmacological Sciences

描述（由申请人提供）：这是一个培训计划的第二次竞争性更新，其主要目标是促进药理学研究生的跨学科培训。它的第二个目标是促进来自爱荷华州大学不同部门和学院的教师和学生之间的互动，这些部门和学院对药理学科学感兴趣。该计划最初于2004年7月获得资助，为期三年，并设有三个博士前职位，为进一步开发处于药理学核心的跨学科课程和培训计划提供必要的初始资源。作为该计划跨学科性质的证据，我们的学员来自三所学院（文科和理科，药学和医学）的六个不同部门（化学，医药和天然产物化学[MNPC]，药理学，生理学，生物化学，解剖学和细胞生物学）。从药理学系外（共27名）招募了19名具有优秀证书的学员，这是一个切实的证据，表明该TG作为一个非常有效的机制，可以吸引学生的兴趣，促进药理学研究生的跨学科培训，而无论部门隶属关系如何。这TG导致了教学，指导和研究的教师和学生在两个核心部门，药理学在卡弗医学院（CCOM），医药和天然产物化学（MNPC）在药学院（COP）在最后一个资助期间的互动显着增加。此外，该计划拥有来自大学的51名优秀教师培训师，有资格获得额外五年的资金。我们的TG从目前的6个名额适度扩大到8个名额是合理的：1）我们的申请人群体的质量和规模，2）我们的实习生群体的多样性（15% URM，41%女性），最重要的是，3）我们毕业生的成功。这个TG的扩展将有助于我们吸引全国学生的能力，以优秀的资格证书，药理科学和促进跨部门和校际合作，在爱荷华州的U。为这个TG建立的课程提供药理学科学的基础和高级教学，并经过不断的审查和修订，以确保它满足计划和学生的需求。两个5周，1学期小时（sh）模块药理学原理（71：135）和药物遗传学和药物基因组学（71：136）作为一个简洁，高效的入门课程序列，为所有学员这个TG。模块化在2010年从3 sh课程，这门课程吸引了相当数量的研究生（5年平均：每年15，其中2/3是来自药理学博士以外。程序）。这些学生来自各个系和博士课程包括药理学，MNPC，分子与细胞生物学，神经科学，生理学与生物物理学，生物化学，解剖学与细胞生物学和化学。入学人数的增加反映了课程的成功重组，除了“核心”（动力学和动力学）分支学科外，还更加强调“现代”（遗传学和基因组学），以及具有共同兴趣的培训员和学员之间加强了互动。我们还专门为该计划的学员举办了一门独特的课程：药理学高级问题解决（71：250）。每个月它都有一个关于药理学研究问题的培训师的深入讲座。在培训师的密切指导下，学生们作为一个小组解决一个问题，并撰写一份实质性的NIH风格的研究提案。最后，所有学员沿着培训师参加半周一次的药理学研讨会（71：204），研讨会由药理学研究生课程的学生、该课程的学员以及博士后研究员和校内校外教师进行研究报告。

DESCRIPTION (provided by applicant): This is the second competitive renewal of a training program whose main goal is to promote the interdisciplinary training of graduate students in Pharmacological Sciences. Its secondary goal is to foster interactions among faculty and students from different departments and colleges at the University of Iowa that share an interest in Pharmacological Sciences. The program was initially funded in July 2004 for a period of three years and with three predoctoral slots to provide the initial resources necessary for further development of an interdisciplinary curriculum and training program that is at the core of the pharmacological sciences. As evidence of the interdisciplinary nature of this program, our trainees come from six different departments (Chemistry, Medicinal & Natural Products Chemistry [MNPC], Pharmacology, Physiology, Biochemistry, Anatomy & Cell Biology) in three colleges (Liberal Arts and Sciences, Pharmacy, and Medicine). The recruitment of 19 trainees with strong-to-outstanding credentials from outside the Department of Pharmacology (of a total of 27) is tangible evidence that this TG functions as a highly effective mechanism to attract the interest and promote the interdisciplinary training of graduate students in the Pharmacological Sciences regardless of departmental affiliation. This TG has led to a significant increase in the teaching, mentoring and research interactions among faculty and students in the two core departments, Pharmacology in the Carver College of Medicine (CCOM), and Medicinal and Natural Products Chemistry (MNPC) in the College of Pharmacy (COP) during the last funding period. Moreover, with a pool of 51 excellent faculty trainers from across the University, the program is strongly positioned to qualify for an additional five years of funding. A modest expansion of our TG from currently 6 to 8 slots is justified by 1) the quality and size of our applicant pool, 2) the diversity of our trainee pool (15% URMs, 41% women), and most importantly, 3) the success of our graduates. An expansion of this TG will aid our ability to attract nationwide students with excellent credentials to the Pharmacological Sciences and foster interdepartmental and intercollegiate collaboration at the U of Iowa. The curriculum established for this TG provides both basic and advanced instruction in Pharmacological Sciences, and has undergone continual review and revision to ensure that it fulfills the needs of the program and the students. The two 5-week, 1 semester hour (sh) modules Principles in Pharmacology (71:135) and Pharmacogenetics and Pharmacogenomics (71:136) serve as a concise and highly effective introductory course sequence for all trainees of this TG. Modularized in 2010 from a 3 sh course, this course sequence attracts a sizable number of graduate students (5-year average: 15 per year, of which 2/3rd are from outside the Pharmacology Ph.D. program). These students come from various departments and Ph.D. programs including Pharmacology, MNPC, Molecular & Cell Biology, Neuroscience, Physiology & Biophysics, Biochemistry, Anatomy & Cell Biology, and Chemistry. The increased enrollment reflects the successful reorganization of the course, enhanced emphasis on "modern" (genetics and genomics) in addition to "core" (dynamics and kinetics) subdisciplines, as well as enhanced interactions between trainers and trainees with common interests. We also host a unique course specifically for trainees of this program: Advanced Problem Solving in Pharmacological Sciences (71:250). Each month it features an in-depth lecture by a trainer on a research problem related to Pharmacological Sciences. Closely mentored by the trainer, students then work as a group to solve a problem and write a substantial NIH style research proposal. Finally, all trainees along with trainers attend the semi-weekly Pharmacology Seminar (71:204), which consists of research presentations by students in the graduate program in Pharmacology, the trainees of this program, as well as postdoctoral fellows and on- and off campus faculty.