Preparation for GTP long-term clinical study on bone health

骨质疏松症是绝经后妇女的一个主要健康问题。我们的长期目标是 开发补充和替代医学(CAM)干预措施，包括 对骨骼健康的饮食补充剂(绿茶多酚，GTP)。总体目标 此U01应用程序的目的是找到最佳剂量的GTP，该剂量将用于 绝经后骨质疏松症妇女长期补充GTP的临床试验。我们的 中心假设是GTP将通过增加骨骼来改善骨骼健康 形成和减少骨吸收。有4个不同的项目参与了 拟议研究：项目1--血清样本中的骨生物标记物测量；项目 2-临床前动物剂量-反应GTP研究；项目3-显示骨密度 测量熟练程度；和项目4--GTP的人体剂量-反应研究。这个 这项研究的意义在于它的CAM方法缓解了骨丢失 绝经后的女性。

Osteoporosis is a major health issue in postmenopausal women. Our long-term goal is to develop a complementary and alternative medicine (CAM) intervention including dietary supplement (green tea polyphenols, GTP) for bone health. The overall objective of this U01 application is to find an optimal dose of GTP that would be employed to a long-term GTP supplementation clinical trial in postmenopausal osteopenic women. Our central hypothesis is that the GTP will improve bone health through increasing bone formation and decreasing bone resorption. There are 4 different projects involved in the proposed study: Project 1 - bone biomarker measurement in the serum samples; Project 2 -preclinical animal dose-response GTP study; Project 3 - demonstrate BMD measurement proficiency; and Project 4 - human dose-response study of GTP. The significance of this study is in its CAM approach to the mitigation of bone loss in postmenopausal women.