ENVIRONMENTAL AND MOLECULAR CARCINOGENESIS

项目摘要（见说明）：环境和分子致癌计划整合了来自纽约大学斯特林森林校区和医学院几个不同部门的27名研究人员（24名正式成员和3名准成员），他们对了解癌症的环境原因有共同的兴趣。该计划的总体目标是了解癌症的环境病因，并利用这些信息进行癌症预防和早期发现。EMC研究计划的重点是以下目标：（1）确定环境致癌物的作用机制，重点关注无机化合物，如砷，镍，铬和镉，通过研究它们对细胞大分子结构和功能的影响;（2）活性氧的形成、它们的生物化学以及它们与细胞相互作用可能产生的生物学效应;（3）致癌物的突变特异性和特定DNA损伤的位点特异性诱变，环境因子遗传易感性的分子基础，激素对基因表达的影响，致癌作用和化学预防;（4）致癌作用的表观遗传机制。为了实现这些目标，该计划的研究按主题分为四组：1）DNA加合物，DNA损伤和修复; 2）致癌作用和动物模型; 3）早期检测和化学预防;以及4）细胞信号传导和致癌作用的表观遗传机制。Max Costa和William Rom博士是该计划的共同领导人。自上次竞争性申请以来，供资总额从17 628 704美元减少到7 570 910美元。成员从47个减少到28个。这一期间的出版物共计323份，其中17%为方案内出版物，16.1%为方案间出版物，4%为方案内和方案间合作出版物

PROJECT SUMMARY (See instructions): The Environmental and Molecular Carcinogenesis Program integrates 27 investigators (24 full members and 3 associate members) from several different departments on NYU campuses of Sterling Forest and the School of Medicine, sharing a common interest in understanding the Environmental causes of cancer. The overall goal of the Program is to understand the environmental etiology of cancer and to use this information for cancer prevention and early detection. The EMC Research Program focuses on the following goals: (1) Identifying the mechanisms of action for environmental carcinogens, with a strong focus on inorganic compounds, such as arsenic, nickel, chromium, and cadmium by investigating their effects on the structure and function of cellular macromolecules; (2) The formation of reactive oxygen species, their biochemistry, and the biological effects that might result from their cellular interactions; (3) The mutational specificity of carcinogens and the site-specific mutagenesis of particular DNA lesions, the molecular basis for genetic susceptibility to environmental agents, the effects of hormones on gene expression, carcinogenesis, and chemoprevention; and (4) Epigenetic mechanisms of carcinogenesis. To achieve these goals, research in this Program is divided thematically into four groups: 1) DNA adducts, DNA Damage and Repair; 2) Carcinogenesis and Animal Models; 3) Early Detection and Chemoprevention; and 4) Cell Signaling and Epigenetic Mechanisms of Carcinogenesis. Drs. Max Costa and William Rom are the Co-Leaders for this Program. Total funding decreased from $17,628,704 to $7,570,910 since the last competitive application. Membership has decreased from 47 to 28. Publications for the period total 323, of which 17% are intraprogrammatic, 16.1% are inter-programmatic, and 4% are both intra- and inter-programmatic collaborations