Biomedical Informatics

生物医学信息学核心(BMIC)的主要目标是促进收集、管理、集成和分析孢子的项目、试点和其他核心有效运作所需的完整的信息类型。这些信息类型的例子包括结构化和半结构化数据集，这些数据集产生于：1)实验研究；2)生物统计分析；3)组织核心和行政操作；4)共享资源服务；以及5)孢子参与者的异步协作。我们将利用俄亥俄州立大学(OSU)生物医学信息学系(OSU-BMI)和俄亥俄州立大学综合癌症中心(OSU-CCC)已经使用或正在开发的生物医学信息学最佳实践和先进技术相结合的方式来实现这一目标。这些技术包括：1)面向服务的caGrid中间件，用于异质生物医学数据源和分析服务之间的电子数据交换；2)高级数据库管理系统，用于存储和查询快速发展的生物医学数据集；3)集中式本体服务和本体锚定的知识发现/管理工具；4)多任务特定的Web门户应用，支持大规模、多维数据集的发现、集成和分析；以及5)基于Web的协作团队科学工具。我们设想BMIC将成为孢子的中央信息协调“枢纽”。为了实现这些目标，生物医学信息学核心的具体目标是：1)开发和支持可扩展的数据库管理系统，供孢子参与者使用；2)实现孢子相关数据源之间的电子数据交换；3)支持特定任务的门户网站应用程序，允许最终用户发现、集成和分析孢子相关数据源；4)通过方便访问OSU-CCC的企业级临床试验管理系统，支持与孢子相关的临床试验的执行；以及5)实施和支持协作性门户网站，旨在作为团队科学和公共传播活动的媒介。

The primary objective of the Biomedical Informatics Core (BMIC) is to facilitate the collection, management, integration, and analysis of a complete spectrum of information types required for the efficient operation of the SPORE'S projects, pilots, and other cores. Examples of these information types include structured and semi-structured data sets resulting from: 1) experimental studies; 2) biostatistical analyses; 3) tissue core and administrative operations; 4) shared resource services; and 5) the asynchronous collaboration of SPORE participants. We will achieve this objective using a combination biomedical informatics best practices and advanced technologies already in use or under development within The Ohio State University (OSU) Department of Biomedical Informatics (OSU-BMI) and The Ohio State University Comprehensive Cancer Center (OSU-CCC). Such technologies include: 1) the service-oriented caGrid middleware for electronic data interchange between heterogeneous biomedical data sources and analytical services; 2) advanced database management systems optimized for the storage and query of rapidly evolving biomedical data sets; 3) centralized ontology services and ontology-anchored knowledge discovery/management tools; 4) multiple task-specific web-portal applications that support the discovery, integration, and analysis of large scale, multi-dimensional data sets; and 5) web-based collaborative team-science tools. We envision the BMIC as being the central information coordination "hub" of the SPORE. In order to achieve these objectives, the specific aims of the biomedical informatics core are to: 1) develop and support extensible database management systems for use by SPORE participants; 2) enable electronic data interchange between SPORE-related data sources; 3) support task-specific web portal applications that allow end users to discover, integrate, and analyze SPORE-related data sources; 4) support the execution of SPORE-related clinical trials through the facilitation of access to the OSU-CCC's enterprise-grade clinical trials management system; and 5) implement and support a collaborative web portal intended to serve as a medium for both team-science and public dissemination activities.