Cell Signaling of Host Defense

国立环境卫生科学研究所呼吸生物学实验室校内研究部宿主防御小组，由Michael B领导。Fessler，MD现在进入了自成立以来在NIEHS的第八年。我们现在已经出版了几份手稿。 自上次年度报告以来的出版物包括： 1)一份合作报告显示沙门氏菌对宿主细胞的侵入在中期是优先的，这是由于胆固醇的外表面小叶分配（桑托斯AJ等，J Cell Sci 2013）。 2)对致《变态反应和临床免疫学杂志》编辑的一封信的邀请回复，该信涉及我们关于美国过敏原特异性IgE与心肌梗塞之间关系的报告（Jaramillo等人，J Allergy Clin Immunol 2013）。 3)一份报告鉴定了肿瘤抑制因子p53在细菌性肺炎期间宿主防御中的新作用（MadenspacherJH等，J Exp Med 2013）。 4)一份鉴定CD 11b/CD 18（Mac-1）为双链RNA的新型细胞表面受体的合作报告（ZhouH等，J Immunol 2013）。 5)一份鉴定载脂蛋白模拟肽通过发挥FPR 2/ALX依赖性趋化活性影响白细胞迁移的报告（Madenspacher JH等，J Biol Chem 2012）。 6)关于低密度脂蛋白对中性粒细胞功能的急性和慢性影响的合作报告（Palvinskaya T等人，Pulm Pharmacol Ther 2013）。 7)一份关于胆固醇转运蛋白ATP结合盒（ABC）A1在骨髓细胞中的表达调节宿主对细胞内病原体单核细胞增生李斯特菌的防御的合作报告（ZhuX等，Circ Res 2012）。 自我们上次报告以来的其他成就包括Fessler博士在北卡罗来纳州州立大学过敏和炎症研讨会、路易斯安那州州立大学兽医学院和2013年戈登血管细胞生物学研究会议上的特邀演讲。Fessler博士还在2013年美国胸科学会国际会议上担任海报会议主持人。 自上次报告以来，Fesslers博士的几名学员也获得了奖项，其中包括暑期学生William Ge（2103年英特尔科学人才搜索和2013年西门子数学，科学和技术竞赛的最终入围者），博士后研究员Kymberly Gowdy（第一名，博士后研究员海报比赛，访问肺学者研讨会，星期五中心），和研究生迈克尔亨德森（获奖者，转化医学研究计划）。

The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its eighth year at the NIEHS since inception. We have now published several manuscripts. Publications since the last annual report include: 1) a collaborative report showing that invasion of host cells by Salmonella is preferential during metaphase due to exofacial leaflet partitioning of cholesterol (Santos AJ et al., J Cell Sci 2013). 2) an invited reply to a Letter to the Editor of the Journal of Allergy and Clinical Immunology addressing our report on the relationship between allergen-specific IgE and myocardial infarction in the U.S. (Jaramillo et al., J Allergy Clin Immunol 2013). 3) a report identifying a novel role for the tumor suppressor p53 in host defense during bacterial pneumonia (Madenspacher JH et al., J Exp Med 2013). 4) a collaborative report identifying CD11b/CD18 (Mac-1) as a novel cell-surface receptor for double-stranded RNA (Zhou H et al., J Immunol 2013). 5) a report identifying that apolipoprotein mimetic peptides influence leukocyte migration through exerting FPR2/ALX-dependent chemotactic activity (Madenspacher JH et al., J Biol Chem 2012). 6) a collaborative report on the acute and chronic effects of low-density lipoprotein on neutrophil function (Palvinskaya T et al., Pulm Pharmacol Ther 2013). 7) a collaborative report that expression of the cholesterol transporter ATP Binding Cassette (ABC)A1 in myeloid cells regulates host defense against the intracellular pathogen Listeria monocytogenes (Zhu X et al., Circ Res 2012). Additional accomplishments since our last report include invited talks by Dr. Fessler at the North Carolina State University Workshop on Allergy and Inflammation, Louisiana State University School of Veterinary Medicine, and the 2013 Gordon Research Conference on Vascular Cell Biology. Dr. Fessler also served as a poster session facilitator at the 2013 American Thoracic Society International Conference. Several of Dr. Fesslers trainees also received awards since the last report, including summer student William Ge (seminfinalist in both 2103 Intel Science Talent Search and 2013 Siemens Competition in Math, Science and Technology), postdoctoral fellow Kymberly Gowdy (First Place, Postdoctoral Fellow Poster Competition, Visiting Pulmonary Scholars Symposium, UNC Friday Center), and graduate student Michael Henderson (awardee, UNC Program in Translational Medicine).