Cancer Center Support Grant

描述（由申请人提供）：本申请为希望之城综合癌症中心（COHCCC）寻求新的CCSG资助。COHCCC汇集了来自希望之城医疗中心和贝克曼研究所34个部门的131名成员。该中心从NCI获得24,212,0996万美元（总计），从其他同行评审来源获得25,947,483万美元，从非同行评审来源获得31,421,929万美元，总体资金总额为81,581,508万美元。通过教师招聘、重组和重要的基础设施建设，COHCCC大大增强了其加速临床和转化癌症研究的能力。新招募了72名教员，其中包括48名临床研究人员和24名基础和人口研究科学家。癌症中心有五个项目：分子肿瘤学（MONC）、发展癌症治疗学（DCT）、癌症免疫治疗学（CI）、血液恶性肿瘤学（HM）和癌症控制与人口科学（CCPS）。中心的会员资格已经得到了磨练，以加强对癌症的关注，并为研究人员创建了一个准会员类别，这些研究人员在同行评审的癌症研究方面的潜力尚未得到发展。此申请要求支持十个共享资源：分析细胞术，分析药理学，生物信息学，功能基因组学/基因组测序，病理学，小动物成像，药物发现和结构生物学，调查研究，生物统计学，临床方案和数据管理。COHCCC准备在未来几年取得重大进展。我们的72名新的基础、人口和临床研究人员将继续引入新的想法、技术和研究重点领域，同时加强中心的创造性和创新环境。已经建立了重要的基础设施和其他资源，以促进将发现转化为快速开发新的癌症治疗方法、诊断测试和其他干预措施，以帮助癌症患者和有恶性肿瘤风险的个人。最后，该机构的整体结构及其在领导、项目协调、发展和权威方面的管理能力得到了增强，从而使癌症中心能够更好地响应其成员的需求，并利用他们的集体能量和创造力。该提案表明，COHCCC已经为实现其使命建立了坚实的结构，并且比以往任何时候都更加强大和可持续。

DESCRIPTION (provided by applicant): This application seeks renewed CCSG funding for the City of Hope Comprehensive Cancer Center (COHCCC). The COHCCC brings together 131 Members from 34 Departments in the City of Hope Medical Center and the Beckman Research Institute. The Center receives $24,212,096M (Totals) from NCI, $25,947,483M from other peer-reviewed sources, and $31,421,929M from non-peer-reviewed sources, for a total of $81,581,508M in overall funding. Through faculty recruitment, reorganization, and significant infrastructure development, the COHCCC has greatly enhanced its ability to accelerate clinical and translational cancer-focused research. Seventy-two new faculty have been recruited, including 48 clinical investigators and 24 basic and population research scientists. The Cancer Center has five Programs: Molecular Oncology (MONC), Developmental Cancer Therapeutics (DCT), Cancer Immunotherapeutics (CI), Hematologic Malignancies (HM), and Cancer Control and Population Sciences (CCPS). Center membership has been honed to sharpen cancer focus and an Associate Member category has been created for investigators whose potential for peer-reviewed, cancer-focused research is yet developing. This application requests support for ten Shared Resources: Analytical Cytometry, Analytical Pharmacology, Bioinformatics, Functional Genomics/Genomic Sequencing, Pathology, Small Animal Imaging, Drug Discovery and Structural Biology, Survey Research, Biostatistics, and Clinical Protocol and Data Management. The COHCCC is primed to make significant advances in the coming years. Our 72 new basic, population and clinical research recruits will continue to introduce new ideas, technologies, and areas of research focus while enhancing the creative and innovative environment of the Center. Significant infrastructure and other resources have been created to facilitate the translation of discoveries to the rapid development of new cancer treatments, diagnostic tests, and other interventions that would aid people with cancer, as well as individuals at risk for malignancy. Finally, the overall configuration of the institution and its administrative capabilities in terms of leadership, programmatic alignment, development, and authority that have been augmented so that the Cancer Center will be more responsive to its members and to harness their collective energies and creativity. This proposal documents that the COHCCC has built a solid structure for achieving its missions and is stronger and more sustainable than it has ever been.