Non-canonical olfactory and vomeronasal receptors

项目摘要 嗅觉神经回路产生数以万计的不同感知和影响 先天行为，如进食，在许多哺乳动物中，信息素反应， 战斗和交配哺乳动物有两种主要的嗅觉组织： 上皮和犁鼻器，其中每一个包含大的家庭， 专门的感觉受体，并激活不同的神经回路。我们最近 确定了两个非典型的哺乳动物化学感受器家族， 不同于先前描述的气味和犁鼻受体。在这一提议中， 我们的目标是了解进化，细胞组织，和化学感受野， 这些新的感觉受体，以提供更多的了解分子 哺乳动物嗅觉的基本机制。

Project Summary Olfactory neural circuits generate tens of thousands of distinct perceptions and influence innate behaviors, such as feeding, and in many mammals, pheromone responses such as fighting and mating. Mammals have two principal olfactory tissues: the main olfactory epithelium and the vomeronasal organ, each of which contains large families of dedicated sensory receptors and activates distinct neuronal circuits. We recently identified two non-canonical families of mammalian chemosensory receptors that are distinct from previously described odorant and vomeronasal receptors. In this proposal, we aim to understand the evolution, cellular organization, and chemoreceptive fields of these novel sensory receptors, to provide additional insight into the molecular mechanisms that underlie olfaction in mammals.