Data & Information Tech Core - Athey

项目摘要（见说明）：密歇根州区域综合代谢组学资源核心（MRC2）的数据和信息技术核心将为定向代谢组学数据的光谱数据分析提供专业知识，并为高通量、非靶向代谢物分析的分析提供重要工具和研究。非靶向代谢组学谱中化合物的鉴定将通过近748种真实代谢物的库的可用性来增强，这些代谢物的光谱特征已在反相和亲水相互作用色谱（HILIC）飞行时间（TOF）上确定，以及在近500份血浆样品中鉴定的已知未知物的库。核心还将在数据分析之前提供数据标准化程序。核心还将负责数据管理、注释和存储，并将与数据存储库和协调中心（DRCC）合作，提供在核心中进行的原始和标准化实验。数据和信息技术核心将与密歇根大学的IT团队合作，维护、故障排除和升级MRC2的信息技术基础设施。

PROJECT SUMMARY (See Instructions): The Data and Information Technology Core of the Michigan Regional Comprehensive Metabolomics Resource Core (MRC2) will provide expertise for the analysis of spectral data from directed metabolomics data and provide important tools and research in the analysis of high-throughput, untargeted metabolite analysis used wider profiling of the metabolome. The identification of compounds in the untargeted metabolomics profile will be enhanced by the availability of a library of nearly 748 authentic metabolites whose spectral features have been determined on reverse phase and hydrophilic interaction chromatography (HILIC) time of flight (TOF) as well as a library of known unknowns' identified in nearly 500 plasma samples. The Core will also provide procedures for data normalization prior to data analysis. The Core also will be responsible for data curation, annotation and storage and will work with the Data Repository and Coordinating Center (DRCC) to provide raw and normalized of experiments performed in the core. The Data and Information Technology Core will work with IT teams within the University of Michigan to maintain, troubleshoot and upgrade the Information Technology infrastructure of the MRC2.