Cross-modal motion responses in blind and deaf humans

项目摘要 尽管作为感觉剥夺的结果的跨模式可塑性已经被记录下来 在各种各样的大脑区域中，我们仍然对如何完成各种任务知之甚少 为什么跨模式会有这样的发展？通常认为，当被剥夺了正常的 输入，大脑区域继续发挥其功能作用，但使用来自其他形式的输入。在……里面 支持这一点的研究表明，MT+是大脑中对视觉运动具有高度选择性的区域 视力正常的人，对早期失明后的听觉和触觉运动有反应。 同样，初级听觉和周围皮质(PAC+)对表观反应敏感 合成声音的运动，可以被严重失聪的视觉运动所激活 研究对象。然而，目前还不清楚这些跨通道反应是否带有任何行为 相关性，或者这些响应是否共享具有正常功能的共同架构。这个 这个提议的项目的目标是使用粗体的组合来解决这些问题 聋人和盲人体内的多体素模式分析和适应技术。

Project Summary Although cross-modal plasticity as a result of sensory deprivation has been documented across a wide variety of brain areas for a wide range of tasks we still have very little idea how or why cross-modal develops as it does. It is generally supposed that, when deprived of normal input, brain areas continue to fulfill their functional role, but use input from other modalities. In support of this, it has been shown that MT+, a brain region highly selective for visual motion in normally sighted individuals, responds to auditory and tactile motion after early blindness. Similarly, primary auditory and surrounding cortex (PAC+), which are sensitive to apparent movement of synthesized sounds, can be activated by visual motion in profoundly deaf subjects. However, it is not clear whether these cross-modal responses carry any behavioral relevance, or whether such responses share common architecture with normal functions. The goal of this proposed project is to address these questions using a combination of BOLD multivoxel pattern analysis and adaptation techniques within both deaf and blind individuals.