Intestinal FABP, dietary fat and Type 2 diabetes in Mexican Americans

肠道脂肪酸结合蛋白2(FABP2)呈现功能性单核苷酸多态Ala54Thr 这导致了两种蛋白质变体：FABP2Ala54和FABP2Thr54。FABP2Thr54变异体表现出双重 与FABP2 Ala54正常相比，脂肪酸结合增加增加了脂肪吸收 肠道，携带者可能表现出更高的胰岛素抵抗和空腹血糖水平的风险。其效果 Ala54Thr SNP在墨西哥裔美国人中没有很好的特征，最近的数据表明它是 在这个民族中与2型糖尿病(T2 DM)相关。此外，约60%的墨西哥裔美国人 我们糖尿病教育计划的糖尿病参与者是FABP2至54携带者，这提供了 有机会评估这种高发病率是否有助于疾病的严重程度。这项研究旨在 了解FABP2 Thr54对患有T2 DM的墨西哥裔美国人的影响。此外，我们将评估 旨在抵消FABP254Thr潜在负面影响的生活方式干预的效果 参与者各不相同。苏氨酸携带者(AT/TT基因型)的个体可能会有不同的相互作用 饮食中含有脂肪，并可能为发展成功的个性化文化提供独特的机会 有效的生活方式干预措施，以减少疾病对墨西哥裔美国人和其他人的影响 受影响的群体。我们的中心假设是墨西哥裔美国人表现出苏氨酸携带者悖论 受FABP2 Ala54Thr多态调控。应用程序的三个目标是：目标1是 FABP2 Ala54Thr基因多态性对MA患者空腹血糖和血脂水平的影响 合并和不合并T2 DM。目的2是确定FABP2 Ala54Thr基因多态对饱和度的影响 脂肪酸引起的脂肪毒性。目的3是测定膳食脂肪和FABP2 Ala54Thr基因的多态性 墨西哥裔美国糖尿病患者空腹血糖和血脂水平的相互作用。完成 这些目标将增加我们对这种SNP在墨西哥T2 DM健康差距中的影响的了解 并可能成为未来个性化糖尿病预防发展的基础 针对这一种族群体的教育计划。

Intestinal fatty acid binding protein 2 (FABP2) exhibits a functional single nucleotide polymorphism, Ala54Thr that result in two protein variants: FABP2 Ala54 and FABP2 Thr54. The FABP2 Thr54 variant exhibits a twofold increase in fatty acid binding compared to the FABP2 Ala54 normal increase fat absorption in the intestine, and carriers may show higher risk for insulin resistance and fasting blood glucose levels. The effect of the Ala54Thr SNP has not been well characterized in Mexican Americans and recent data suggest it is associated with type 2 diabetes (T2DM) in this ethnic group. Further, about 60% of Mexican American diabetic participants in our diabetes education program are FABP2 Thr54 carriers which provide an opportunity to assess if this high incidence may contribute to the severity of the disease. This study seeks to understand the effect of the FABP2 Thr54 in Mexican Americans with T2DM. Further, we will evaluate the effect of a lifestyle intervention designed to counteract the potential negative effect ofthe FABP2 54Thr variant in participants. Individuals shown to be threonine carriers (AT/TT genotypes) may interact differently with dietary fat and may provide an unique opportunity to develop successful personalized cultural competent lifestyle interventions to reduce the impact of the disease on Mexican Americans and other affected groups. Our central hypothesis is that Mexican Americans exhibit a threonine-carrier paradox modulated by the FABP2 Ala54Thr polymorphism. The three aims of the application are: Aim 1 is to determine the effect ofthe FABP2 Ala54Thr polymorphism on fasting blood glucose and lipid levels in MA with and without T2DM. Aim 2 is to determine the effect of the FABP2 Ala54Thr polymorphism on saturated fatty acid-induced lipotoxicity. Aim 3 is to determine the dietary fat and FABP2 Ala54Thr polymorphism interactions on fasting blood glucose and lipids levels in diabetic Mexican-Americans. The completion of these aims will increase our knowledge of the effects of this SNP in T2DM health disparities in Mexican Americans and may serve as foundation for the development of future personalized prevention diabetes education program targeting this ethnic group.