Educating Physician-Neuroscientists: The R25 at UCSF

项目总结/摘要 医生科学家短缺，选择进入研究职业的医生人数很少。 下降。这种短缺威胁着生物医学研究企业的机会， 医生神经科学家作出实质性的发现，有助于理解和治疗 神经系统疾病（如：阿尔茨海默病、中风、癫痫、帕金森病）有所增加 美国国立卫生研究院（NIH）制定了一个路线图，鼓励以疾病为导向的 在支持性学术环境中进行研究，包括特别强调提高 为医生和科学家提供培训方案。 目前医生-科学家管道减少的一个原因是需要长时间的培训， 实现研究独立。首次获得NIH R 01补助金的人的平均年龄（通常使用的 研究独立性的措施）已经达到43年的MD申请人谁面临独特的挑战， 走向研究独立的道路。当医生完成临床住院医师培训并 准备申请职业发展基金，许多人已经到了30多岁。这一时期的特点是， 重要的生活方式决定（例如-有一个家庭，成为经济独立，购买第一套住房） 和职业发展决策。加上年底平均约15万美元的债务， 这些经济和生活方式的因素联合收割机阻止潜在的医生科学家， 从事与低收入、低资助率和长期研究相关的研究工作， 安全其他职业途径（例如-私人执业，行业）可能似乎更有吸引力的许多 最聪明的医生 R25研究教育计划通过提供新的 资源，以协助有前途的医生研究人员改善培训，指导，支持性研究 环境和资源，最大限度地提高从培训成功过渡的可能性 独立的研究环境。神经内科、神经外科和放射科 加州大学旧金山分校弗朗西斯科（UCSF）致力于解决 通过鼓励居民在研究期间发展或扩展调查追求， 临床训练年。UCSF的神经病学系非常适合作为主要的 临床神经科学研究教育计划的赞助商，下面详细介绍，这是这个项目的重点。 应用程序.

Project Summary/Abstract There is a shortage of physician scientists and the number of physicians choosing to enter research careers is declining. This shortage threatens the biomedical research enterprise at a time when the opportunities for physician-neuroscientists to make substantial discoveries contributing to understanding and treatment of nervous system diseases (e.g.-Alzheimer disease, stroke, epilepsy, Parkinson disease) have increased dramatically.1 The National Institute of Health (NIH) has developed a roadmap to encourage disease-oriented research in supportive academic environments, including a special emphasis on improving the success rate of training programs for physician-scientists.2 One reason for the current decline in the physician-scientist pipeline is the long training period required to reach research independence. The average age of a first-time NIH R 01 grant recipient (one commonly used measure of research independence) has reached 43 years for MD applicants who face unique challenges on the path to research independence. By the time physicians have completed clinical residency training and are ready to apply for career development funding, many have reached their late 30s. This period is marked by important lifestyle decisions (e.g.-having a family, becoming financially independent, purchasing a first home) and career development decisions. Coupled with an average debt of approximately $150,000 at the end of medical school, these financial and lifestyle factors combine to discourage potential physician-scientists from embarking on research careers associated with low income, low rates of grant funding, and little long term security. Other career avenues (e.g.-private practice, industry) may seem more attractive for many of the brightest physicians in training. The R25 research education program implements the vision of the NIH roadmap at NINDS by providing new resources to assist promising physician investigators with improved training, mentorship, a supportive research environment, and resources that maximize the probability of a successful transition from the training environment to independent research careers. The Departments of Neurology, Neurosurgery, and Radiology at the University of California, San Francisco (UCSF) are committed to addressing the problem of declining interest in research careers by encouraging residents to develop or extend investigative pursuits during the clinical training years. The Department of Neurology at UCSF is well positioned to serve as the primary sponsor of the clinical neuroscience research education program, detailed below, that is the focus of this application.